((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol

Base Information

Chemical Name:((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol
CAS No.:1623755-25-8
Molecular Formula:C₃₆H₅₀O₄Si
Molecular Weight:574.876
Hs Code.:

Synonyms:((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol

Suppliers and Price of ((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of ((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol

There total 7 articles about ((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1623755-23-6
2-((1R,2R,4S)-2-(hydroxymethyl)-4-((triisopropylsilyl)oxy)cyclobutyl)ethanol

: 14470-28-1
mono-4-methoxytrityl chloride

: 1623755-25-8
((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol

: 1623755-73-6
2-((1R,2R,4S)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-4-((triisopropylsilyl)oxy)cyclobutyl)ethanol

: 1643956-22-2
C₅₆H₆₆O₅Si

Guidance literature:: With pyridine; dmap; In dichloromethane; at -42 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201400617

Reference yield:

: 1623755-21-4
((1S,5R,6S)-bicyclo[3.2.0]hept-2-en-6-yloxy)triisopropylsilane

: 1623755-25-8
((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol

: 1623755-73-6
2-((1R,2R,4S)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-4-((triisopropylsilyl)oxy)cyclobutyl)ethanol

: 1643956-22-2
C₅₆H₆₆O₅Si

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / dichloromethane; methanol / -78 °C

1.2: dehumidified air / 3 h / -78 - 20 °C

2.1: dmap; pyridine / dichloromethane / 2 h / -42 °C / Inert atmosphere

With pyridine; dmap; ozone; In methanol; dichloromethane;
DOI:10.1002/anie.201400617

Reference yield:

: 13259-28-4
bicyiclo<3.2.0>hept-2-en-6-ol

: 1623755-25-8
((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol

: 1623755-73-6
2-((1R,2R,4S)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-4-((triisopropylsilyl)oxy)cyclobutyl)ethanol

: 1643956-22-2
C₅₆H₆₆O₅Si

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

2.1: potassium dihydrogenphosphate / tert-butyl methyl ether; pentane / 20 °C / pH 7 / Resolution of racemate; Enzymatic reaction

3.1: lithium hydroxide monohydrate / methanol; water / 0.5 h / 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5.1: ozone / dichloromethane; methanol / -78 °C

5.2: dehumidified air / 3 h / -78 - 20 °C

6.1: dmap; pyridine / dichloromethane / 2 h / -42 °C / Inert atmosphere

With pyridine; 1H-imidazole; dmap; potassium dihydrogenphosphate; lithium hydroxide monohydrate; ozone; In methanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; pentane;
DOI:10.1002/anie.201400617