2-(4-(5-(4-chlorophenylsulfonamido)-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetic acid

Base Information

Chemical Name:2-(4-(5-(4-chlorophenylsulfonamido)-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetic acid
CAS No.:1080521-25-0
Molecular Formula:C₂₄H₁₉ClN₂O₇S
Molecular Weight:514.943
Hs Code.:

Synonyms:2-(4-(5-(4-chlorophenylsulfonamido)-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetic acid

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Chemical Property of 2-(4-(5-(4-chlorophenylsulfonamido)-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetic acid

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Technology Process of 2-(4-(5-(4-chlorophenylsulfonamido)-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetic acid

There total 7 articles about 2-(4-(5-(4-chlorophenylsulfonamido)-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080522-79-7
ethyl 2-(4-(5-amino-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetate

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 1080521-25-0
2-(4-(5-(4-chlorophenylsulfonamido)-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: ethyl 2-(4-(5-amino-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetate; 4-chlorobenzenesulfonyl chloride; With 2,6-dimethylpyridine; In tetrahydrofuran; at 70 ℃;

With sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 86984-32-9
6‐chloro‐5‐nitroquinoline

: 1080521-25-0
2-(4-(5-(4-chlorophenylsulfonamido)-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dimethyl sulfoxide / 4 h / 80 °C

2.1: sulfuric acid / 15 h / Heating / reflux

3.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 20 °C

4.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 8 h / 0 - 20 °C

5.1: hydrogen / palladium on activated charcoal / ethanol / 6 h / 20 °C

6.1: 2,6-dimethylpyridine / tetrahydrofuran / 70 °C

6.2: 5 h / 20 °C

With 2,6-dimethylpyridine; sulfuric acid; hydrogen; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform; dimethyl sulfoxide;

Reference yield:

: 1080522-70-8
2-(3-methoxy-4-(5-nitroquinolin-6-yloxy)phenyl)acetic acid

: 1080521-25-0
2-(4-(5-(4-chlorophenylsulfonamido)-2-oxo-1,2-dihydroquinolin-6-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 15 h / Heating / reflux

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 20 °C

3.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 8 h / 0 - 20 °C

4.1: hydrogen / palladium on activated charcoal / ethanol / 6 h / 20 °C

5.1: 2,6-dimethylpyridine / tetrahydrofuran / 70 °C

5.2: 5 h / 20 °C

With 2,6-dimethylpyridine; sulfuric acid; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;