ethyl [(1R,2R,3S,4R,5RS)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-5-{N³-(4-chlorophenyl)-1-ureidyl}-1,4-heptofuranos-5-yl]uronoate

Base Information

• Chemical Name: ethyl [(1R,2R,3S,4R,5RS)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-5-{N³-(4-chlorophenyl)-1-ureidyl}-1,4-heptofuranos-5-yl]uronoate
• CAS No.: 623559-51-3
• Molecular Formula: C₂₆H₃₁ClN₂O₇
• Molecular Weight: 518.994
• Mol file: 623559-51-3.mol

Synonyms:ethyl [(1R,2R,3S,4R,5RS)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-5-{N³-(4-chlorophenyl)-1-ureidyl}-1,4-heptofuranos-5-yl]uronoate

Chemical Property of ethyl [(1R,2R,3S,4R,5RS)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-5-{N³-(4-chlorophenyl)-1-ureidyl}-1,4-heptofuranos-5-yl]uronoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl [(1R,2R,3S,4R,5RS)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-5-{N³-(4-chlorophenyl)-1-ureidyl}-1,4-heptofuranos-5-yl]uronoate

There total 2 articles about ethyl [(1R,2R,3S,4R,5RS)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-5-{N³-(4-chlorophenyl)-1-ureidyl}-1,4-heptofuranos-5-yl]uronoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

p-chlorphenylisocyanate (104-12-1) + ethyl [5-amino-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene]-heptofuranuronate (500908-09-8) → ethyl [(1R,2R,3S,4R,5RS)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-5-{N3-(4-chlorophenyl)-1-ureidyl}-1,4-heptofuranos-5-yl]uronoate (623559-51-3)

Guidance literature:

In dichloromethane; at 30 ℃; for 4h;

DOI:10.1016/S0968-0896(03)00214-1

Reference yield:

ethyl (Z)-[3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-α-D-gluco]-heptofuran-5-en-uronate (108788-48-3) → ethyl [(1R,2R,3S,4R,5RS)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-5-{N3-(4-chlorophenyl)-1-ureidyl}-1,4-heptofuranos-5-yl]uronoate (623559-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ / ethanol

2: 90 percent / CH₂Cl₂ / 4 h / 30 °C

With ammonia; In ethanol; dichloromethane;

DOI:10.1016/S0968-0896(03)00214-1

Reference yield: 80.0%

ethyl [(1R,2R,3S,4R,5RS)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-5-{N3-(4-chlorophenyl)-1-ureidyl}-1,4-heptofuranos-5-yl]uronoate (623559-51-3) → (S)-6-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-(4-chloro-phenyl)-dihydro-pyrimidine-2,4-dione

Guidance literature:

With 4 A molecular sieve; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; for 2.5h; Heating;

DOI:10.1016/S0968-0896(03)00214-1

upstream raw materials:

p-chlorphenylisocyanate

ethyl [5-amino-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene]-heptofuranuronate

ethyl (Z)-[3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-α-D-gluco]-heptofuran-5-en-uronate