2-(4-(3-bromophenyl)butanoyl)-N-ethylhydrazinecarboxamide

Base Information

• Chemical Name: 2-(4-(3-bromophenyl)butanoyl)-N-ethylhydrazinecarboxamide
• CAS No.: 1616372-70-3
• Molecular Formula: C₁₃H₁₈BrN₃O₂
• Molecular Weight: 328.209
• Mol file: 1616372-70-3.mol

Synonyms:2-(4-(3-bromophenyl)butanoyl)-N-ethylhydrazinecarboxamide

Chemical Property of 2-(4-(3-bromophenyl)butanoyl)-N-ethylhydrazinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(3-bromophenyl)butanoyl)-N-ethylhydrazinecarboxamide

There total 4 articles about 2-(4-(3-bromophenyl)butanoyl)-N-ethylhydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-bromophenyl)butanehydrazide (1596464-90-2) + ethyl isocyanate (109-90-0) → 2-(4-(3-bromophenyl)butanoyl)-N-ethylhydrazinecarboxamide (1616372-70-3)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

4-(3-bromophenyl)-butyric acid (899350-32-4) → 2-(4-(3-bromophenyl)butanoyl)-N-ethylhydrazinecarboxamide (1616372-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Carbonyldiimidazole / tetrahydrofuran / 1.5 h

1.2: 0.5 h

2.1: tetrahydrofuran / 12 h / 20 °C

With Carbonyldiimidazole; In tetrahydrofuran;

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → 2-(4-(3-bromophenyl)butanoyl)-N-ethylhydrazinecarboxamide (1616372-70-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium cyanide / N,N-dimethyl-formamide / 0.5 h / 45 °C

1.2: 3.33 h / 45 °C

2.1: hydrazine hydrate; potassium hydroxide; water / ethylene glycol / 195 °C

3.1: Carbonyldiimidazole / tetrahydrofuran / 1.5 h

3.2: 0.5 h

4.1: tetrahydrofuran / 12 h / 20 °C

With sodium cyanide; Carbonyldiimidazole; water; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; ethylene glycol; N,N-dimethyl-formamide;

upstream raw materials:

4-(3-bromophenyl)-butyric acid

4-(3-bromophenyl)butanehydrazide

ethyl isocyanate

m-bromobenzoic aldehyde

Downstream raw materials:

N-((3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-[1,1'-biphenyl]-3-yl)methyl)benzenesulfonamide

3-(3-(3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)propyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

3-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-methoxy-[1,1'-biphenyl]-3-yl)propanoic acid

3-(3-(3'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)propyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one