2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate

Base Information

Chemical Name:2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate
CAS No.:1355996-41-6
Molecular Formula:C₂₁H₂₅NO₃
Molecular Weight:339.434
Hs Code.:

Synonyms:2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate

Suppliers and Price of 2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate

There total 13 articles about 2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1355996-24-5
2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]-ethanol

: 97-72-3
2-Methylpropionic anhydride

: 1355996-41-6
2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/acschemneuro.6b00050

Reference yield:

: 1222136-74-4
[(1S,2S)-2-(5-(benzyloxy)pyridin-3-yl)cyclopropyl]methanol

: 1355996-41-6
2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.92 h / Inert atmosphere; Cooling with acetone-dry ice

1.2: 0.75 h / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 3.58 h / 0 - 20 °C / Inert atmosphere

3.1: borane-THF / tetrahydrofuran; cyclohexane / 0.08 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 - 55 °C / Inert atmosphere

4.1: dmap; triethylamine / dichloromethane / 2 h / Inert atmosphere

With dmap; borane-THF; oxalyl dichloride; sodium hexamethyldisilazane; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; cyclohexane; 1.1: Swern oxidation / 2.1: Wittig reaction;
DOI:10.1021/jm201157c

Reference yield:

: 1222137-77-0
(1S,2S)-2-[5-(benzyloxy)-3-pyridyl]cyclopropanecarboxaldehyde

: 1355996-41-6
2-[(1R,2S)-2-[5-(benzyloxy)pyridin-3-yl]cyclopropyl]ethyl isobutyrate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 3.58 h / 0 - 20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran; cyclohexane / 0.08 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 - 55 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 2 h / Inert atmosphere

With dmap; borane-THF; sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran; dichloromethane; cyclohexane; 1.1: Wittig reaction;
DOI:10.1021/jm201157c