MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE
• CAS No.: 91641-50-8
• Molecular Formula: C12H15 N O3 . Cl H
• Molecular Weight: 257.71334
• Mol file: 91641-50-8.mol

Synonyms:4-Morpholineaceticacid, a-phenyl-, hydrochloride (6CI,7CI)

Chemical Property of MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE

Chemical Property:

• PSA: 49.77000
• LogP: 1.88440
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(Morpholin-4'-yl)phenylaceticacidhydrochloride 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE

There total 3 articles about MORPHOLIN-4-YL-PHENYL-ACETIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-morpholine methyl phenylacetate (100609-91-4) → 2-morpholino-2-phenylacetic acid hydrochloride (91641-50-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 110 ℃; for 24h;

Reference yield:

2-bromophenylacetic acid (4870-65-9,31302-84-8) → 2-morpholino-2-phenylacetic acid hydrochloride (91641-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / methanol / 24 h / Reflux

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 24 h / 110 °C

With hydrogenchloride; sulfuric acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; acetonitrile;

Reference yield:

bromo-phenyl-acetic acid methyl ester (37167-62-7,3042-81-7,61139-20-6) → 2-morpholino-2-phenylacetic acid hydrochloride (91641-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 24 h / 110 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;

upstream raw materials:

2-bromophenylacetic acid

bromo-phenyl-acetic acid methyl ester

α-morpholine methyl phenylacetate