(R)-{(4R,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-phenyl-methanol

Base Information

Chemical Name:(R)-{(4R,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-phenyl-methanol
CAS No.:189079-60-5
Molecular Formula:C₂₀H₃₄O₄Si
Molecular Weight:366.573
Hs Code.:

Synonyms:(R)-{(4R,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-phenyl-methanol

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Chemical Property of (R)-{(4R,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-phenyl-methanol

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Technology Process of (R)-{(4R,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-phenyl-methanol

There total 10 articles about (R)-{(4R,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-phenyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 189079-61-6
(R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-((4S,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-propan-1-ol

: 189079-60-5
(R)-{(4R,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-phenyl-methanol

Guidance literature:: With pyridinium p-toluenesulfonate; In acetonitrile; for 8h; Ambient temperature;

Reference yield:

: 1053734-98-7
(1R,2S,3R)-2-Benzyloxy-1-phenyl-pentane-1,3,5-triol

: 189079-60-5
(R)-{(4R,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-phenyl-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, DMAP / CH₂Cl₂ / 8 h / Ambient temperature

2: PPTS / dimethylformamide / 2 h / Ambient temperature

With dmap; pyridinium p-toluenesulfonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 2-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionaldehyde

: 189079-60-5
(R)-{(4R,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-phenyl-methanol

Guidance literature:: Multi-step reaction with 7 steps

1: SnCl₄ / CH₂Cl₂ / 0.17 h / -78 °C

2: CH₂Cl₂ / 0.25 h / Ambient temperature

3: DIBAL-H / CH₂Cl₂; toluene / 0.25 h / -78 °C

4: NaBH₄ / methanol / 30 h / Ambient temperature

5: TBAF / tetrahydrofuran / 0.5 h / Ambient temperature

6: Et₃N, DMAP / CH₂Cl₂ / 8 h / Ambient temperature

7: PPTS / dimethylformamide / 2 h / Ambient temperature

With dmap; sodium tetrahydroborate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; tin(IV) chloride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;