Technology Process of 2-hydroxy-2-methyl-8,8-diphenyloct-7-enoic acid
There total 6 articles about 2-hydroxy-2-methyl-8,8-diphenyloct-7-enoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 2-hydroxy-2-methyl-8,8-diphenyloct-7-enoate;
With
water; lithium hydroxide;
In
tetrahydrofuran;
for 6h;
Reflux;
With
sodium hydrogen sulfate;
pH=4;
Cooling;
DOI:10.1039/c0ob00588f
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.75 h / 0 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: water; lithium hydroxide / tetrahydrofuran / 6 h / Reflux
2.2: pH 4 / Cooling
With
n-butyllithium; water; diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; hexane;
DOI:10.1039/c0ob00588f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl dichloride
2.1: tetrahydrofuran
3.1: toluene-4-sulfonic acid / benzene
4.1: sodium iodide / acetone / 20 °C
5.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.75 h / 0 °C / Inert atmosphere
5.2: -78 - 20 °C
6.1: water; lithium hydroxide / tetrahydrofuran / 6 h / Reflux
6.2: pH 4 / Cooling
With
n-butyllithium; oxalyl dichloride; water; toluene-4-sulfonic acid; diisopropylamine; sodium iodide; lithium hydroxide;
In
tetrahydrofuran; hexane; acetone; benzene;
DOI:10.1039/c0ob00588f
