[(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester

Base Information

• Chemical Name: [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester
• CAS No.: 1421312-36-8
• Molecular Formula: C₂₀H₁₈N₂O₅
• Molecular Weight: 366.373
• Mol file: 1421312-36-8.mol

Synonyms:[(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester

Chemical Property of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester

There total 28 articles about [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

C22H23N3O5 → [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester (1421312-36-8)

Guidance literature:

With zinc; at 80 ℃; for 5h; under 760.051 Torr;

Reference yield: 85.1%

4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid (1421312-35-7) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester (1421312-36-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water; at 40 ℃;

Reference yield:

3-hydroxy-α-methylbenzylamine (63720-38-7) → [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester (1421312-36-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 90 - 100 °C

2.1: sodium hydroxide / 240 °C

2.2: Reflux

3.1: potassium iodide; potassium carbonate / 90 - 100 °C

4.1: sodium hydroxide / 60 °C

5.1: potassium iodide; hydrogenchloride / water

6.1: ethanol; sodium hydroxide / 30 - 55 °C

7.1: triethylamine; N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate

With hydrogenchloride; ethanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide; In water;

upstream raw materials:

4-Nitrophthalonitrile

4-phenoxyphthalonitrile

4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid

glycine ethyl ester hydrochloride

Downstream raw materials:

[(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid