3-methyl-2,4-diphenylpyridine

Base Information

• Chemical Name: 3-methyl-2,4-diphenylpyridine
• CAS No.: 875228-76-5
• Molecular Formula: C₁₈H₁₅N
• Molecular Weight: 245.324
• Mol file: 875228-76-5.mol

Synonyms:3-methyl-2,4-diphenylpyridine

Chemical Property of 3-methyl-2,4-diphenylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-methyl-2,4-diphenylpyridine

There total 10 articles about 3-methyl-2,4-diphenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(E)-1-phenylpropan-1-one O-acetyl oxime (1426021-96-6) + 3-phenyl-propenal (104-55-2) → 3-methyl-2,4-diphenylpyridine (875228-76-5)

Guidance literature:

With copper(l) iodide; diisopropylamine; In dimethyl sulfoxide; at 60 ℃; for 16h; Reagent/catalyst; regioselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/ja312346s

Reference yield: 80.0%

C16H16N2O2 + 3-phenyl-propenal (104-55-2) → 3-methyl-2,4-diphenylpyridine (875228-76-5)

Guidance literature:

With ammonium iodide; triethylamine; In toluene; at 120 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1039/c7ob02471a

Reference yield: 78.0%

1-phenylpropan-1-one O-acetyl oxime (133145-92-3) + 3-phenyl-propenal (104-55-2) → 3-methyl-2,4-diphenylpyridine (875228-76-5)

Guidance literature:

With iodine; triethylamine; In toluene; at 120 ℃; for 3h; chemoselective reaction;

DOI:10.1021/acs.joc.5b02624

upstream raw materials:

6-chloro-3-methyl-2,4-diphenyl-pyridine

3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine

3-benzoyl-1-ethyl-4-phenyl-4-hydroxypiperidine

sulfuric acid