(S)-(+)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

Base Information

Chemical Name:(S)-(+)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one
CAS No.:854019-26-4
Molecular Formula:C₁₅H₁₈N₂O₃
Molecular Weight:274.32
Hs Code.:

Synonyms:(S)-(+)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

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Chemical Property of (S)-(+)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

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Technology Process of (S)-(+)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

There total 3 articles about (S)-(+)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 854019-25-3
(R)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

: 854019-26-4
(S)-(+)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

Guidance literature:: 4-methyl-benzaldehyde; urea; With 2,4,6-trichlorobenzoic acid; tert-gutylammonium 2,2,2-trifluoroacetate; In dichloromethane; at 25 ℃; for 1h;

ethyl acetoacetate; With N-[(1R,2R)-2-aminocyclohexyl]-N'-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-thiourea; In dichloromethane; at 25 ℃; for 72h; optical yield given as %ee;
DOI:10.1002/adsc.200900597

Reference yield:

: C₉H₁₀N₂O

: 141-97-9
ethyl acetoacetate

: 854019-25-3
(R)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

: 854019-26-4
(S)-(+)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

Guidance literature:: With C₁₅H₂₄N₂O₂; In tetrahydrofuran; 1,4-dioxane; at 25 ℃; for 132h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chem.200701581

Reference yield:

: 299949-24-9
ethyl 6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 854019-25-3
(R)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

: 854019-26-4
(S)-(+)-5-ethoxycarbonyl-6-methyl-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

Guidance literature:: With tetraproline chiral stationary phase packed on HPLC column; In hexane; isopropyl alcohol; Resolution of racemate;
DOI:10.1002/chir.22001