Technology Process of 3-(4-phenylpiperazine-1-carbonyl)-N-(4-propylphenyl)benzenesulfonamide
There total 4 articles about 3-(4-phenylpiperazine-1-carbonyl)-N-(4-propylphenyl)benzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C17H19NO4S;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
Inert atmosphere;
1-phenylpiperazine hydrochloride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere
2.1: hydrogenchloride / methanol / 2 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / methanol / 2 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
methanol; N,N-dimethyl-formamide;