77278-63-8

Basic information

• Product Name: TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE;1-Boc-4-Phenylpiperazine;1-Piperazinecarboxylicacid, 4-phenyl-, 1,1-diMethylethyl ester;4-Phenylpiperazine-1-carboxylic acid tert-butyl ester;N-(tert-Butoxycarbonyl)-N'-phenylpiperazine
• CAS NO: 77278-63-8
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.35
• Mol File: 77278-63-8.mol
• Article Data: 24

Chemical Properties

• Melting Point: 70-71℃
• Boiling Point: 372.2 °C at 760 mmHg
• Flash Point: 178.9 °C
• Appearance: /
• Density: 1.093 g/cm³
• PKA: 3.29±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE(77278-63-8)
• EPA Substance Registry System: TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE(77278-63-8)

Safety Data

• Hazardous Substances Data: 77278-63-8(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE, also known as Tert-Butyl 4-phenylpiperazine-1-carboxylate, is a chemical compound with the molecular formula C17H24N2O2. It is a tertiary butyl ester derivative of 4-phenylpiperazine-1-carboxylic acid and is commonly used in pharmaceutical research as a potential precursor to psychoactive compounds and in the development of new drugs. TERT-BUTYL 4-PHENYLPIPERAZINE-1-CARBOXYLATE is known to have potential therapeutic properties but also carries significant health and safety hazards, including its irritant effects on the skin, eyes, and respiratory system, as well as its flammability, and it should be handled with caution.

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1193466-76-0 tert-butyl 4-chloropiperazine-1-carboxylate 
• 1078-58-6 diphenylzinc 
• 62-53-3 aniline 
• 159635-50-4 Bis-(2-bromo-ethyl)-carbamic acid tert-butyl ester 
• 108-90-7 chlorobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 201230-82-2 carbon monoxide 
• 75-65-0 tert-butyl alcohol 
• 98-80-6 phenylboronic acid 
• 77278-40-1 tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate 
• 780-69-8 triethoxyphenylsilane 
• 110-52-1 1,4-dibromo-butane 

Downstream Products

• 92-54-6 4-phenyl-1-piperazine 
• 100957-44-6 1-(furan-2-ylmethyl)-4-phenylpiperazine 
• 845973-49-1 tert-butyl 3-oxo-4-phenylpiperazine-1-carboxylate 
• 1245034-88-1 N-(4-butylphenyl)-4-methyl-3-(4-phenylpiperazine-1-carbonyl)benzenesulfonamide 
• 1311383-01-3 3-(4-phenylpiperazine-1-carbonyl)-N-(4-propylphenyl)benzenesulfonamide 
• 1268862-34-5 2-phenyl-3-(4-phenylpiperazin-1-yl)quinoxaline-6-carboxylic acid 
• 1268865-24-2 methyl 2-phenyl-3-(4-phenylpiperazin-1-yl)quinoxaline-6-carboxylate 
• 4004-95-9 1-phenylpiperazine hydrochloride 

Relevant articles and documents

Mediator-Enabled Electrocatalysis with Ligandless Copper for Anaerobic Chan-Lam Coupling Reactions

Simple copper salts serve as catalysts to effect C-X bond-forming reactions in some of the most utilized transformations in synthesis, including the oxidative coupling of aryl boronic acids and amines. However, these Chan-Lam coupling reactions have historically relied on chemical oxidants that limit their applicability beyond small-scale synthesis. Despite the success of replacing strong chemical oxidants with electrochemistry for a variety of metal-catalyzed processes, electrooxidative reactions with ligandless copper catalysts are plagued by slow electron-transfer kinetics, irreversible copper plating, and competitive substrate oxidation. Herein, we report the implementation of substoichiometric quantities of redox mediators to address limitations to Cu-catalyzed electrosynthesis. Mechanistic studies reveal that mediators serve multiple roles by (i) rapidly oxidizing low-valent Cu intermediates, (ii) stripping Cu metal from the cathode to regenerate the catalyst and reveal the active Pt surface for proton reduction, and (iii) providing anodic overcharge protection to prevent substrate oxidation. This strategy is applied to Chan-Lam coupling of aryl-, heteroaryl-, and alkylamines with arylboronic acids in the absence of chemical oxidants. Couplings under these electrochemical conditions occur with higher yields and shorter reaction times than conventional reactions in air and provide complementary substrate reactivity.

MONOACYLGLYCEROL LIPASE INHIBITORS

Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

Copper-Catalyzed Electrophilic Amination of Alkoxyarylsilanes

We report a copper-catalyzed amination reaction between simple alkoxyarylsilanes and N-benzoyloxyamines. Silver fluoride serves as a stoichiometric base as well as an indispensable activator that allows the catalytic process to proceed. Multiply alkoxylated arylsilanes, such as trialkoxyarylsilanes and dialkoxyarylsilanes were transformed into the corresponding tertiary anilines under mild reaction conditions.