1-hexanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

Base Information

• Chemical Name: 1-hexanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide
• CAS No.: 945267-47-0
• Molecular Formula: C₂₆H₃₁N₃O₂
• Molecular Weight: 417.551

Synonyms:1-hexanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

Chemical Property of 1-hexanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

Chemical Property:

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Technology Process of 1-hexanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

There total 3 articles about 1-hexanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-hexanoylamino-cyclopentanecarboxylic acid (945267-45-8) + [(2'-cyanobiphenyl-4-yl)methyl]amine (133690-92-3) → 1-hexanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (945267-47-0)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 25 - 35 ℃;

DOI:10.1515/HC.2006.12.5.323

Reference yield:

Hexanoyl chloride (142-61-0) → 1-hexanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (945267-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / sodium hydroxide / H₂O; toluene / 2 h / 0 - 10 °C

2: 90 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH₂Cl₂ / 25 - 35 °C

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; water; toluene;

DOI:10.1515/HC.2006.12.5.323

Reference yield:

1-amino-1-cyclopentanecarboxylic acid (52-52-8) → 1-hexanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide (945267-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / sodium hydroxide / H₂O; toluene / 2 h / 0 - 10 °C

2: 90 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH₂Cl₂ / 25 - 35 °C

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; water; toluene;

DOI:10.1515/HC.2006.12.5.323

upstream raw materials:

1-hexanoylamino-cyclopentanecarboxylic acid

[(2'-cyanobiphenyl-4-yl)methyl]amine

Hexanoyl chloride

1-amino-1-cyclopentanecarboxylic acid

Downstream raw materials:

4'-(2-pentyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)biphenyl-2-carbonitrile

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