sodium (5R^*,6S^*)-2-(4'-hydroxymethylphenyl)-6-<(R^*)-1-hydroxyethyl>-1-carbapen-2-em-3-carboxylate

Base Information

• Chemical Name: sodium (5R^*,6S^*)-2-(4'-hydroxymethylphenyl)-6-<(R^*)-1-hydroxyethyl>-1-carbapen-2-em-3-carboxylate
• CAS No.: 88140-20-9
• Molecular Formula: C₁₆H₁₆NO₅*Na
• Molecular Weight: 325.297

Synonyms:sodium (5R^*,6S^*)-2-(4'-hydroxymethylphenyl)-6-<(R^*)-1-hydroxyethyl>-1-carbapen-2-em-3-carboxylate

Chemical Property of sodium (5R^*,6S^*)-2-(4'-hydroxymethylphenyl)-6-<(R^*)-1-hydroxyethyl>-1-carbapen-2-em-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of sodium (5R^*,6S^*)-2-(4'-hydroxymethylphenyl)-6-<(R^*)-1-hydroxyethyl>-1-carbapen-2-em-3-carboxylate

There total 8 articles about sodium (5R^*,6S^*)-2-(4'-hydroxymethylphenyl)-6-<(R^*)-1-hydroxyethyl>-1-carbapen-2-em-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-nitrobenzyl-(5R*,6S*)-2-(4'-hydroxymethylphenyl)-6-<(R*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-1-carbapen-2-em-3-carboxylate (88140-19-6) → sodium (5R*,6S*)-2-(4'-hydroxymethylphenyl)-6-<(R*)-1-hydroxyethyl>-1-carbapen-2-em-3-carboxylate (88140-20-9)

Guidance literature:

With ethanol; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; for 0.75h; under 2327.2 Torr;

DOI:10.1016/S0040-4020(01)92147-7

Reference yield:

2-((4-bromobenzyl)oxy)tetrahydro-2H-pyran (17100-68-4) → sodium (5R*,6S*)-2-(4'-hydroxymethylphenyl)-6-<(R*)-1-hydroxyethyl>-1-carbapen-2-em-3-carboxylate (88140-20-9)

Guidance literature:

Multi-step reaction with 4 steps

2: 78 percent / 10percent H₂SO₄ aq. / acetic acid / 0.5 h / Ambient temperature

3: 68 percent / xylene / 1.5 h / Heating

4: 50 percent Spectr_. / 1) aq. NaHCO₃, 2) abs EtOH / 2) 10percent Pd/C / dioxane / 0.75 h / 2327.2 Torr

With ethanol; sulfuric acid; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; acetic acid; xylene;

DOI:10.1016/S0040-4020(01)92147-7

Reference yield:

4-bromobenzenemethanol (873-75-6) → sodium (5R*,6S*)-2-(4'-hydroxymethylphenyl)-6-<(R*)-1-hydroxyethyl>-1-carbapen-2-em-3-carboxylate (88140-20-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / p-TsOH / CH₂Cl₂ / 2 h / Ambient temperature

3: 78 percent / 10percent H₂SO₄ aq. / acetic acid / 0.5 h / Ambient temperature

4: 68 percent / xylene / 1.5 h / Heating

5: 50 percent Spectr_. / 1) aq. NaHCO₃, 2) abs EtOH / 2) 10percent Pd/C / dioxane / 0.75 h / 2327.2 Torr

With ethanol; sulfuric acid; sodium hydrogencarbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; acetic acid; xylene;

DOI:10.1016/S0040-4020(01)92147-7

upstream raw materials:

o-nitrobenzyl-(5R^*,6S^*)-2-(4'-hydroxymethylphenyl)-6-<(R^*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-1-carbapen-2-em-3-carboxylate

2-((4-bromobenzyl)oxy)tetrahydro-2H-pyran

4-bromobenzenemethanol

{(2R,3S)-2-(2-Hydroxy-ethyl)-3-[(R)-1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 2-nitro-benzyl ester

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