(E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

Base Information

• Chemical Name: (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid
• CAS No.: 158979-65-8
• Molecular Formula: C₂₀H₁₈O₈
• Molecular Weight: 386.358
• Mol file: 158979-65-8.mol

Synonyms:(E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

Chemical Property of (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

There total 6 articles about (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.1%

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (88775-49-9) → (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (158979-65-8)

Guidance literature:

In acetone; for 48h; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4020(01)85506-X

Reference yield: 24.6%

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (88775-49-9) → 1,t-2-bis(3,4,5-trimethoxyphenyl)-c-2,t-4-bis(3,4-methylenedioxybenzoyl)-r-1,t-3-cyclobutanedicarboxylic acid (158979-69-2) + (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (158979-65-8)

Guidance literature:

In solid; for 62h; Irradiation;

DOI:10.1016/S0040-4020(01)85506-X

Reference yield:

4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyronitrile (88775-24-0) → (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (158979-65-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 40.2 percent / DDQ / benzene / 18.5 h / Heating; in the dark

2: 80 percent / methanol / 8 h / Heating

3: 85.8 percent / 10percent NaOH / methanol; H₂O / 1.5 h / Heating

4: 26.4 percent / solid / 62 h / Irradiation

With sodium hydroxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; water; benzene;

DOI:10.1016/S0040-4020(01)85506-X

upstream raw materials:

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyronitrile

(E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile