5-carbamoyl-2-[(N,N-dimethylaminomethylen)amino]-3-p-tolylpyrimidin-4(3H)-one

Base Information

• Chemical Name: 5-carbamoyl-2-[(N,N-dimethylaminomethylen)amino]-3-p-tolylpyrimidin-4(3H)-one
• CAS No.: 1262446-50-3
• Molecular Formula: C₁₅H₁₇N₅O₂
• Molecular Weight: 299.332

Synonyms:5-carbamoyl-2-[(N,N-dimethylaminomethylen)amino]-3-p-tolylpyrimidin-4(3H)-one

Chemical Property of 5-carbamoyl-2-[(N,N-dimethylaminomethylen)amino]-3-p-tolylpyrimidin-4(3H)-one

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Technology Process of 5-carbamoyl-2-[(N,N-dimethylaminomethylen)amino]-3-p-tolylpyrimidin-4(3H)-one

There total 1 articles about 5-carbamoyl-2-[(N,N-dimethylaminomethylen)amino]-3-p-tolylpyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-amino-5-carbamoyl-3-p-tolylpyrimidin-4(3H)-one (1262446-43-4) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 5-carbamoyl-2-[(N,N-dimethylaminomethylen)amino]-3-p-tolylpyrimidin-4(3H)-one (1262446-50-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2010.10.059

Reference yield: 94.0%

Methoxyacetyl chloride (38870-89-2) + 5-carbamoyl-2-[(N,N-dimethylaminomethylen)amino]-3-p-tolylpyrimidin-4(3H)-one (1262446-50-3) → 3-carbamoyl-7-methoxy-1-p-tolyl-1H-pyrimido[1,2-a]pyrimidine-2,6-dione (1262446-62-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/j.tet.2010.10.059

Reference yield: 72.0%

3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) + 5-carbamoyl-2-[(N,N-dimethylaminomethylen)amino]-3-p-tolylpyrimidin-4(3H)-one (1262446-50-3) → 3-carbamoyl-7-methoxycarbonyl-1-p-tolyl-1H-pyrimido[1,2-a]pyrimidine-2,6-dione (1262446-60-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 9h;

DOI:10.1016/j.tet.2010.10.059

upstream raw materials:

2-amino-5-carbamoyl-3-p-tolylpyrimidin-4(3H)-one

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

3-carbamoyl-7-methoxy-1-p-tolyl-1H-pyrimido[1,2-a]pyrimidine-2,6-dione

3-carbamoyl-7-methoxycarbonyl-1-p-tolyl-1H-pyrimido[1,2-a]pyrimidine-2,6-dione

3-carbamoyl-1-p-tolyl-1H-pyrimido[1,2-a]pyrimidine-2,6-dione

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