{(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone

Base Information

Chemical Name:{(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone
CAS No.:1597518-39-2
Molecular Formula:C₂₇H₂₄ClN₃O₂
Molecular Weight:457.959
Hs Code.:

Synonyms:{(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone

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Chemical Property of {(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone

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Technology Process of {(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone

There total 8 articles about {(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2840-46-2
4-methyl-[1,1‘-biphenyl]-2-carboxylic acid

: 1597528-46-5
3-(3-chloro-2-methylphenyl)-5-(S)-pyrrolidin-2-yl-[1,2,4]oxadiazole

: 1597518-39-2
{(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 54454-12-5
(3-chloro-2-methylphenyl)carbonitrile

: 1597518-39-2
{(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; sodium hydrogencarbonate / 24 h / 20 - 80 °C

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 3 h / 20 °C

3: 1,4-dioxane / 48 h / 75 °C

4: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

With hydroxylamine hydrochloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1597528-11-4
(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1597518-39-2
{(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;