2840-46-2

Usage

Uses

Used in Chemical Synthesis:
[1,1'-Biphenyl]-2-carboxylic acid, 4-methylis used as a building block in the chemical synthesis industry for the creation of other organic compounds. Its unique structure and functional groups allow for versatile reactions and the formation of a wide range of derivatives.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, [1,1'-Biphenyl]-2-carboxylic acid, 4-methylis used as a starting material for the development of new drugs. Its aromatic structure and functional groups make it a promising candidate for the design of novel therapeutic agents.
Used in Research and Development:
[1,1'-Biphenyl]-2-carboxylic acid, 4-methylis also utilized in research and development settings, where it may be investigated for potential biological or medicinal properties. Its unique structure could provide insights into new mechanisms of action or reveal novel applications in the field of drug discovery.

Upstream product

• 1436849-24-9 4-methyl-N-(quinolin-8-yl)-[1,1'-biphenyl]-2-carboxamide 
• 17852-28-7 2-amino-5-methylbenzophenone 
• 4433-10-7 2,4-dimethyl-1,1'-biphenyl 

Downstream Products

• 644-08-6 4-Methylbiphenyl 
• 92-92-2 biphenyl-4-carboxylic acid 
• 92-52-4 biphenyl 
• 1042719-86-7 2-(2-phenyl-5-methylphenyl)-1,3-benzoxazole 
• 1384120-93-7 ((1S,6R)-3-(6,7-difluoroquinoxalin-2-yl)-3,8-diazabicyclo[4.2.0]octan-8-yl)(4-methyl-[1,1'-biphenyl]-2-yl)methanone 
• 1597518-39-2 {(S)-2-[3-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-5-yl]pyrrolidin-1-yl}-(4-methylbiphenyl-2-yl)methanone 

Relevant academic research and scientific papers

Method for synthesis of sand smooth biphenyl

The invention discloses a synthetic method of 2-cyano-4'-methylbiphenyl, which adopts paratoluidine and benzoyl chloride as raw materials; a Friedel-Crafts acylation reaction is carried out under a Lewis acid catalysis condition; then a ring-closure reaction of a diazonium salt and a benzene ring is carried out in the presence of sodium nitrite; ring opening is carried out under an alkaline condition to generate a main product as shown in formula VI and a byproduct as shown in formula VII, and the ring-opening products are prepared into salts which are then subjected to separation; and finally, carboxyl groups are converted into cyan groups to obtain 2-cyano-4'-methylbiphenyl. The synthetic method of the invention has the advantages of easily available raw materials, safety, convenience for production management, low cost, reduction in 'three wastes' pollution, byproduct recyclability, and improved atom utilization rate.

Ruthenium-catalyzed direct arylation of C-H bonds in aromatic amides containing a bidentate directing group: Significant electronic effects on arylation

Arylation of ortho C-H bonds is achieved by a ruthenium-catalyzed reaction of aromatic amides having an 8-aminoquinoline moiety with aryl bromides. The reaction shows high functional group compatibility. The reaction proceeds in a highly selective manner at the less hindered C-H bonds of meta-substituted aromatic amides. Significant electronic effects are observed in Hammett plots. Electron-withdrawing groups on the aromatic amides facilitate the reaction. In contrast, both electron-donating groups and electron-withdrawing groups on aryl bromides accelerate the reaction. The Royal Society of Chemistry 2013.

Liquid-Phase Catalytic Oxidation of 2,4-Dimethylbiphenyl

2,4-Dimethylbiphenyl synthesized by alkylalion of m-xylene with cyclohexanol and subsequent dehydrogenation was oxidized catalytically in the liquid phase to 2,4-biphenyldicarboxylic acid. The effects of temperature, the catalyst, and initial concentrations of reactants on the rate and efficiency of the process were studied.