(R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

Base Information

Chemical Name:(R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate
CAS No.:1613463-69-6
Molecular Formula:C₅₀H₅₃N₅O₇
Molecular Weight:836
Hs Code.:

(R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

Synonyms:(R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

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Chemical Property of (R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

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Technology Process of (R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

There total 8 articles about (R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 411211-77-3
N-benzyl-3,3-diethoxypropan-1-amine

: (R)-quinuclidin-3-yl ((S)-(3-((4-((3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

: 1613463-69-6
(R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

Guidance literature:: (R)-quinuclidin-3-yl ((S)-(3-((4-((3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-benzyl-3,3-diethoxypropan-1-amine; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2021.127975

Reference yield:

: 42116-44-9
N-tert-butoxycarbonylbenzylamine

: 1613463-69-6
(R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 24 h / 80 °C

2.1: hydrogenchloride / methanol; 1,4-dioxane / 7 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 18 h / 20 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2021.127975

Reference yield:

: C₁₉H₃₁NO₄

: 1613463-69-6
(R)-quinuclidin-3-yl ((S)-(3-((4-(benzyl(3-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)propyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol; 1,4-dioxane / 7 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 18 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2021.127975