4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid

Base Information

• Chemical Name: 4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid
• CAS No.: 1613414-00-8
• Molecular Formula: C₂₉H₃₀N₂O₅
• Molecular Weight: 486.568
• Mol file: 1613414-00-8.mol

Synonyms:4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid

Chemical Property of 4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid

There total 16 articles about 4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Methyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)-phenoxy) methyl)benzoate (1613413-99-2) → 4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid (1613414-00-8)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

(R)-quinuclidin-3-yl carbonochloridate → 4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid (1613414-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 17 h / 0 - 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

With pyridine; water; lithium hydroxide; In tetrahydrofuran;

Reference yield:

(S)-tert-butyl ((3-hydroxyphenyl)(phenyl)methyl)carbamate (1416069-62-9) → 4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid (1613414-00-8)

Guidance literature:

Multi-step reaction with 5 steps

1: CHIRALPAK AD 20 / isopropyl alcohol; n-heptane; diethylamine / 25 °C / Resolution of racemate

2: potassium carbonate / acetonitrile / 16 h / 20 °C

3: hydrogenchloride / methanol; 1,4-dioxane / 16 h / 20 °C

4: pyridine / 17 h / 0 - 20 °C

5: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

With pyridine; hydrogenchloride; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; diethylamine; isopropyl alcohol; acetonitrile;

upstream raw materials:

3-methoxybenzophenone

3-hydroxybenzophenone

N-((3-hydroxyphenyl)(phenyl)methyl)formamide

3-(Amino(phenyl)methyl)phenol hydrochloride

Downstream raw materials:

2-(4-formyl-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate

4-(2-(((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)-amino)ethyl)benzyl 3-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)-methyl)phenoxy)methyl)benzoate

3-((((R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)benzyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate

3-(1,3-Dioxolan-2-yl)propyl 1-methyl-5((3((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)-1H-pyrazole-3-carboxylate