C₁₉H₃₄O₂Si

Base Information

• Chemical Name: C₁₉H₃₄O₂Si
• CAS No.: 1195757-50-6
• Molecular Formula: C₁₉H₃₄O₂Si
• Molecular Weight: 322.563
• Mol file: 1195757-50-6.mol

Synonyms:C₁₉H₃₄O₂Si

Chemical Property of C₁₉H₃₄O₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₃₄O₂Si

There total 16 articles about C₁₉H₃₄O₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(2S)-6-(benzyloxy)hexan-2-ol + tert-butyldimethylsilyl chloride (18162-48-6) → C19H34O2Si (1195757-50-6)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetasy.2016.02.007

Reference yield:

4-benzyloxybutanal (5470-84-8) → C19H34O2Si (1195757-50-6)

Guidance literature:

Multi-step reaction with 6 steps

1: benzene / 4 h / Inert atmosphere; Reflux

2: diisobutylaluminium hydride / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: titanium(IV)isopropoxide; Cumene hydroperoxide; diethyl (2R,3R)-tartrate / dichloromethane / 12 h / -20 - 0 °C / Inert atmosphere; Molecular sieve

4: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

5: diisobutylaluminium hydride / dichloromethane; toluene / 12 h / -20 - 20 °C / Inert atmosphere

6: 1H-imidazole / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; diethyl (2R,3R)-tartrate; Cumene hydroperoxide; titanium(IV)isopropoxide; diisobutylaluminium hydride; triethylamine; In dichloromethane; toluene; benzene; 3: |Sharpless Asymmetric Epoxidation;

DOI:10.1016/j.tetasy.2016.02.007

Reference yield:

4-benzyloxy-butan-1-ol (4541-14-4) → C19H34O2Si (1195757-50-6)

Guidance literature:

Multi-step reaction with 7 steps

1: oxalyl dichloride; triethylamine; dimethyl sulfoxide / dichloromethane / -78 °C / Inert atmosphere

2: benzene / 4 h / Inert atmosphere; Reflux

3: diisobutylaluminium hydride / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4: titanium(IV)isopropoxide; Cumene hydroperoxide; diethyl (2R,3R)-tartrate / dichloromethane / 12 h / -20 - 0 °C / Inert atmosphere; Molecular sieve

5: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

6: diisobutylaluminium hydride / hexane / 4 h / 0 - 20 °C / Inert atmosphere

7: 1H-imidazole / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; oxalyl dichloride; diethyl (2R,3R)-tartrate; Cumene hydroperoxide; titanium(IV)isopropoxide; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In hexane; dichloromethane; benzene; 1: |Swern Oxidation / 4: |Sharpless Asymmetric Epoxidation;

DOI:10.1016/j.tetasy.2016.02.007

upstream raw materials:

tert-butyldimethylsilyl chloride

1-[(3-bromopropoxy)methyl]-benzene

(R)-6-(benzyloxy)-2-hydroxyhexyl-4-methylbenzenesulfonate

4-benzyloxy-butan-1-ol

Downstream raw materials:

(3E,6S,9E,11S,14S)-11-hydroxy-6,14-dimethyl-1,7-dioxacyclotetradeca-3,9-diene-2,5,8-trione