Technology Process of 3a-[(R)-5-(4-bromo-2-fluorobenzyl)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ6-[1,4,3]oxathiazin-2-ylamino]hexahydro-2,5-methanopentalene-2-carboxamide
There total 10 articles about 3a-[(R)-5-(4-bromo-2-fluorobenzyl)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4λ6-[1,4,3]oxathiazin-2-ylamino]hexahydro-2,5-methanopentalene-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
dichloromethane;
at 35 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: magnesium / tetrahydrofuran; tert-butyl methyl ether / 55 °C
2: acetic acid; sodium hypochlorite; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; water / 0 - 25 °C
3: water; sodium hydroxide; bromine / 1,4-dioxane / -15 - 20 °C
4: diphenyl phosphoryl azide; triethylamine / Reflux
5: ruthenium trichloride; sodium periodate / water; acetonitrile; tetrachloromethane / 20 °C
6: ammonia; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; methanol / 2 h / 20 °C
7: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C
8: dichloromethane / 16 h / 35 °C
With
hydrogenchloride; ruthenium trichloride; sodium hypochlorite; sodium periodate; diphenyl phosphoryl azide; ammonia; water; bromine; tetra-(n-butyl)ammonium iodide; magnesium; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: water; sodium hydroxide; bromine / 1,4-dioxane / -15 - 20 °C
2: diphenyl phosphoryl azide; triethylamine / Reflux
3: ruthenium trichloride; sodium periodate / water; acetonitrile; tetrachloromethane / 20 °C
4: ammonia; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; methanol / 2 h / 20 °C
5: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C
6: dichloromethane / 16 h / 35 °C
With
hydrogenchloride; ruthenium trichloride; sodium periodate; diphenyl phosphoryl azide; ammonia; water; bromine; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide;
In
1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
