38584-33-7Relevant academic research and scientific papers
Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors
Plewe, Michael B.,Sokolova, Nadezda V.,Gantla, Vidyasagar Reddy,Brown, Eric R.,Naik, Shibani,Fetsko, Alexandra,Lorimer, Donald D.,Lorimer, Donald D.,Dranow, David M.,Dranow, David M.,Smutney, Hayden,Smutney, Hayden,Bullen, Jameson,Bullen, Jameson,Sidhu, Rana,Sidhu, Rana,Master, Arshil,Master, Arshil,Wang, Junru,Wang, Junru,Kallel, E. Adam,Zhang, Lihong,Kalveram, Birte,Freiberg, Alexander N.,Henkel, Greg,McCormack, Ken
supporting information, p. 1160 - 1167 (2020/05/14)
We identified and explored the structure-activity-relationship (SAR) of an adamantane carboxamide chemical series of Ebola virus (EBOV) inhibitors. Selected analogs exhibited half-maximal inhibitory concentrations (EC50 values) of ～10-15 nM in vesicular s
ADAMANTANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION
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Paragraph 0908-0909, (2020/02/05)
Compounds of structural Formula I were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus, wherein, R1, R2, R3, X and Y are defined in the specification.
Ring-fused compound, pharmaceutical composition containing same and application of compound
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Paragraph 0244-0246, (2018/04/01)
The invention discloses a ring-fused compound, a preparation method thereof, pharmaceutical composition containing the compound and an application of the compound. A polycyclic compound (I) as well asan isomer, a prodrug, a stable isotopic derivative or pharmacologically acceptable salt of the compound (I) has the following structure. The polycyclic compound has good IDO1 and/or TDO2 inhibition functions, can effectively treat, relieve and/or prevent various diseases which are related with IDO1 and/or TDO2, such as cancer, virus infection, autoimmune diseases or the like.
Polycyclic compound as well as pharmaceutical composition and application thereof
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Paragraph 0299; 0300; 0301; 0302, (2018/03/26)
The invention discloses a polycyclic compound as well as a preparation method, a pharmaceutical composition and application thereof. The polycyclic compound (I), isomers, prodrugs, solvent compounds,hydrates, stable isotope derivatives or pharmaceutically
ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION
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Page/Page column 90; 91, (2017/09/02)
Compounds of structural Formula (I) were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus.
BENZYL-OXATHIAZINE DERIVATIVES SUBSTITUTED WITH ADAMANTANE AND NORADAMANTANE, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF
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Paragraph 0281; 0282; 0283, (2014/02/15)
The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.
NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF
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Paragraph 0216; 0217; 0218, (2014/02/15)
The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.
L -DIHYDRO-2-OXOQUINOLINE COMPOUNDS A 5-HT4 RECEPTOR LIGANDS
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, (2011/04/18)
The present invention relates to novel l,2-dihydro-2-oxoquinoline compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. Formula (I) The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The compounds of the present invention are useful in the treatment/prevention of various disorders that are mediated by 5-HT4 receptor activity.
NOVEL DIPEPTIDYL PEPTIDASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 31; 49-50, (2008/06/13)
The present invention relates to novel compounds representated by formula (I), where R, R1, R2, R3, X, Y, m, n are as defined.The present invention relates to compounds of the general formula I their derivatives, their analogs, their tautomeric forms, their stereoisomers, their diastereomers, their bioisosteres, their polymorphs, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them which are predominantly dipeptidyl peptidase IV inhibitors. The present invention also relates to the processes for the preparation of novel compounds of formula (I) and their use in treating type II diabetes and diabetic complications thereof and also for treating dislipidemia, hypercholesterolemia, obesity and hyperglycemia.
