2-methylthio-5-methyl-6-[1-(4-fluorophenyl)-1-hydroxymethyl]-4(3H)-pyrimidinone

Base Information

Chemical Name:2-methylthio-5-methyl-6-[1-(4-fluorophenyl)-1-hydroxymethyl]-4(3H)-pyrimidinone
CAS No.:948859-53-8
Molecular Formula:C₁₃H₁₃FN₂O₂S
Molecular Weight:280.323
Hs Code.:

Synonyms:2-methylthio-5-methyl-6-[1-(4-fluorophenyl)-1-hydroxymethyl]-4(3H)-pyrimidinone

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Chemical Property of 2-methylthio-5-methyl-6-[1-(4-fluorophenyl)-1-hydroxymethyl]-4(3H)-pyrimidinone

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Technology Process of 2-methylthio-5-methyl-6-[1-(4-fluorophenyl)-1-hydroxymethyl]-4(3H)-pyrimidinone

There total 3 articles about 2-methylthio-5-methyl-6-[1-(4-fluorophenyl)-1-hydroxymethyl]-4(3H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 948859-52-7
2-methylthio-5-methyl-6-formyl-4(3H)-pyrimidinone

: 352-13-6
4-flourophenylmagnesium bromide

: 948859-53-8
2-methylthio-5-methyl-6-[1-(4-fluorophenyl)-1-hydroxymethyl]-4(3H)-pyrimidinone

Guidance literature:: In tetrahydrofuran; at -15 - 20 ℃;
DOI:10.1021/ol071225i

Reference yield:

: 948859-51-6
6-(diethoxymethyl)-5-methyl-2-(methylthio)pyrimidin-4(3H)-one

: 948859-53-8
2-methylthio-5-methyl-6-[1-(4-fluorophenyl)-1-hydroxymethyl]-4(3H)-pyrimidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / trifluoroacetic acid / 1 h / Heating

2: 65 percent / tetrahydrofuran / -15 - 20 °C

With trifluoroacetic acid; In tetrahydrofuran; 2: Grignard reaction;
DOI:10.1021/ol071225i

Reference yield:

: 24132-51-2
ethyl 4,4-diethoxy-2-methyl-3-oxobutanoate

: 948859-53-8
2-methylthio-5-methyl-6-[1-(4-fluorophenyl)-1-hydroxymethyl]-4(3H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / calcium hydroxide / ethanol; H₂O / 48 h / 20 °C

2: 99 percent / trifluoroacetic acid / 1 h / Heating

3: 65 percent / tetrahydrofuran / -15 - 20 °C

With calcium hydroxide; trifluoroacetic acid; In tetrahydrofuran; ethanol; water; 3: Grignard reaction;
DOI:10.1021/ol071225i