tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

Base Information

Chemical Name:tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate
CAS No.:1086282-13-4
Molecular Formula:C₃₂H₃₄N₂O₆
Molecular Weight:542.632
Hs Code.:

Synonyms:tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

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Chemical Property of tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

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Technology Process of tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

There total 4 articles about tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl chloro(oxo)acetate

: 1086282-01-0
tert-butyl 2-oxo-1-(biphenyl-4-yl)-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate

: 1086282-13-4
tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

Guidance literature:: tert-butyl 2-oxo-1-(biphenyl-4-yl)-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate; With sec.-butyllithium; (-)-sparteine; In tetrahydrofuran; at -78 ℃; for 1h;

With copper(l) cyanide; lithium chloride; In tetrahydrofuran; at -78 ℃; for 0.666667h;

methyl chloro(oxo)acetate; In tetrahydrofuran; at -78 - 20 ℃; for 1.16667h;

Reference yield:

: 59-48-3
2-oxoindole

: 1086282-13-4
tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / Dimethyl ether / 1.17 h / -78 - -30 °C

1.2: 48 h / -30 - 20 °C

2.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / acetonitrile / 15 h / 40 - 80 °C

3.1: sec.-butyllithium; (-)-sparteine / tetrahydrofuran / 1 h / -78 °C

3.2: 0.67 h / -78 °C

3.3: 1.17 h / -78 - 20 °C

With copper(l) iodide; sec.-butyllithium; potassium carbonate; lithium hexamethyldisilazane; (-)-sparteine; N,N`-dimethylethylenediamine; In tetrahydrofuran; Dimethyl ether; acetonitrile;

Reference yield:

: 118753-70-1
N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine

: 1086282-13-4
tert-butyl 1-biphenyl-4-yl-2'-[methoxy(oxo)acetyl]-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / Dimethyl ether / 1.17 h / -78 - -30 °C

1.2: 48 h / -30 - 20 °C

2.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / acetonitrile / 15 h / 40 - 80 °C

3.1: sec.-butyllithium; (-)-sparteine / tetrahydrofuran / 1 h / -78 °C

3.2: 0.67 h / -78 °C

3.3: 1.17 h / -78 - 20 °C

With copper(l) iodide; sec.-butyllithium; potassium carbonate; lithium hexamethyldisilazane; (-)-sparteine; N,N`-dimethylethylenediamine; In tetrahydrofuran; Dimethyl ether; acetonitrile;