1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

Chemical Name:1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
CAS No.:252882-60-3
Molecular Formula:C17H22N2O3
Molecular Weight:302.373
Hs Code.:2933399090
Mol file:252882-60-3.mol

Synonyms:1,2-Dihydro-2-oxo-spiro[3h-indole-3,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester;1'-Boc-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine];tert-Butyl 2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate;

Suppliers and Price of 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1''-Boc-1,2-dihydro-2-oxo-spiro[3h-indole-3,4''-piperidine]
100mg
$ 295.00

Synthonix
tert-Butyl2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate 95+%
5g
$ 1820.00

SynQuest Laboratories
tert-Butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate
250 mg
$ 122.00

Matrix Scientific
1'-Boc-1,2-dihydro-2-oxo-spiro-[3H-indole-3,4'-piperidine] 95+%
500mg
$ 180.00

Matrix Scientific
1'-Boc-1,2-dihydro-2-oxo-spiro-[3H-indole-3,4'-piperidine] 95+%
1g
$ 265.00

Matrix Scientific
1'-Boc-1,2-dihydro-2-oxo-spiro-[3H-indole-3,4'-piperidine] 95+%
5g
$ 795.00

Labseeker
tert-Butyl2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate 98
10g
$ 1835.00

J&W Pharmlab
1''-Boc-1,2-dihydro-2-oxo-spiro[3H-indole-3,4''-piperidine] 96%
5g
$ 380.00

Crysdot
1'-Boc-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] 95+%
25g
$ 980.00

Crysdot
1'-Boc-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] 95+%
10g
$ 649.00

Total 42 raw suppliers

Chemical Property of 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

Boiling Point:475.6 °C at 760 mmHg
PKA:13.83±0.20(Predicted)
Flash Point:241.4 °C
PSA：58.64000
Density:1.22 g/cm³
LogP:2.98330
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1''-Boc-1,2-dihydro-2-oxo-spiro[3h-indole-3,4''-piperidine] ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

There total 10 articles about 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 252882-61-4
spiro[indoline-3,4'-piperidin]-2-one

: 24424-99-5
di-tert-butyl dicarbonate

: 252882-60-3
tert-butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield: 81.0%

: 59-48-3
2-oxoindole

: 118753-70-1
N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine

: 252882-60-3
tert-butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate

Guidance literature:: 2-oxoindole; With lithium hexamethyldisilazane; In 1,2-dimethoxyethane; at -78 - -30 ℃; for 1.16667h;

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine; In 1,2-dimethoxyethane; at -30 - 20 ℃; for 66h;
DOI:10.1021/jm201542d