2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone

Base Information

• Chemical Name: 2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone
• CAS No.: 160744-84-3
• Molecular Formula: C₃₆H₄₁N₃O₄
• Molecular Weight: 579.739
• Mol file: 160744-84-3.mol

Synonyms:2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone

Chemical Property of 2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone

There total 1 articles about 2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dimethoxyphenylacetyl chloride (10313-60-7) + [(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone (160744-78-5) → 2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone (160744-84-3)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, -30 degC;

DOI:10.1016/S0040-4039(00)73518-0

Reference yield: 92.0%

2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone (160744-84-3) → (R)-1-[2-(3,4-Dimethoxy-phenyl)-acetyl]-4-(2-oxo-ethyl)-1,4-dihydro-pyridine-3-carbaldehyde (160744-85-4)

Guidance literature:

With hydrogenchloride; In diethyl ether;

DOI:10.1016/S0040-4039(00)73518-0

Reference yield:

2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone (160744-84-3) → (R)-4-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-ylmethyl)-1,4-dihydro-pyridine-3-carbaldehyde

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / 5percent HCl / diethyl ether

2: molecular sieves 4 Angstroem / diethyl ether

3: 60 percent / NaOH / methanol; CH₂Cl₂ / 1 h

With hydrogenchloride; sodium hydroxide; 4 A molecular sieve; In methanol; diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(00)73518-0

upstream raw materials:

3,4-dimethoxyphenylacetyl chloride

[(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone

Downstream raw materials:

(R)-1-[2-(3,4-Dimethoxy-phenyl)-acetyl]-4-(2-oxo-ethyl)-1,4-dihydro-pyridine-3-carbaldehyde

(R)-1-[2-(3,4-Dimethoxy-phenyl)-acetyl]-4-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-ylmethyl)-1,4-dihydro-pyridine-3-carbaldehyde