[(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone

Base Information

• Chemical Name: [(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone
• CAS No.: 160744-78-5
• Molecular Formula: C₃₃H₃₅N₃O₂
• Molecular Weight: 505.66
• Mol file: 160744-78-5.mol

Synonyms:[(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone

Chemical Property of [(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone

There total 1 articles about [(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoyl chloride (98-88-4) + 3-(1,3-Dimethyl-4(S),5(S)-diphenylimidazolidin-2-yl)pyridine (133634-31-8) + C4H7CuO → [5-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-((Z)-2-ethoxy-vinyl)-2H-pyridin-1-yl]-phenyl-methanone + [(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone (160744-78-5) + [(R)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone

Guidance literature:

In tetrahydrofuran; Yield given; from -70 degC to 0 degC;

DOI:10.1016/S0040-4039(00)73518-0

Reference yield: 68.0%

[(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone (160744-78-5) → (S)-1-Benzoyl-4-((Z)-2-ethoxy-vinyl)-1,4-dihydro-pyridine-3-carbaldehyde (160744-80-9)

Guidance literature:

With hydrogenchloride; In diethyl ether;

DOI:10.1016/S0040-4039(00)73518-0

Reference yield:

[(S)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-phenyl-methanone (160744-78-5) → ((R)-1-Benzoyl-3-formyl-1,4-dihydro-pyridin-4-yl)-acetic acid methyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / 2percent HCl / diethyl ether

2: 5percent HCl / diethyl ether

3: 50 percent / (NH₄)2S₂O₈, H₂SO₄ / 2 h / 0 °C

With hydrogenchloride; ammonium peroxydisulfate; sulfuric acid; In diethyl ether;

DOI:10.1016/S0040-4039(00)73518-0

upstream raw materials:

benzoyl chloride

3-(1,3-Dimethyl-4(S),5(S)-diphenylimidazolidin-2-yl)pyridine

Downstream raw materials:

2-(3,4-Dimethoxy-phenyl)-1-[(S)-3-((4S,5S)-1,3-dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-((Z)-2-ethoxy-vinyl)-4H-pyridin-1-yl]-ethanone

(S)-1-Benzoyl-4-((Z)-2-ethoxy-vinyl)-1,4-dihydro-pyridine-3-carbaldehyde

(R)-1-Benzoyl-4-(2-oxo-ethyl)-1,4-dihydro-pyridine-3-carbaldehyde

(R)-1-[2-(3,4-Dimethoxy-phenyl)-acetyl]-4-(2-oxo-ethyl)-1,4-dihydro-pyridine-3-carbaldehyde