3-(8-Hydroxyquinolin-2-YL)prop-2-enoic acid

Base Information

Chemical Name:3-(8-Hydroxyquinolin-2-YL)prop-2-enoic acid
CAS No.:91493-45-7
Molecular Formula:C12H9 N O3
Molecular Weight:215.208
Hs Code.:
DSSTox Substance ID:DTXSID30697245
Mol file:91493-45-7.mol

Synonyms:3-(8-HYDROXYQUINOLIN-2-YL)PROP-2-ENOIC ACID;DTXSID30697245

Suppliers and Price of 3-(8-Hydroxyquinolin-2-YL)prop-2-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
3-(8-hydroxy-quinolin-2-yl)-acrylicacid 95
25g
$ 3245.00

Total 4 raw suppliers

Chemical Property of 3-(8-Hydroxyquinolin-2-YL)prop-2-enoic acid

Chemical Property:

PSA：70.42000
LogP:2.03820
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:215.058243149
Heavy Atom Count:16
Complexity:290

Purity/Quality:

99% ^*data from raw suppliers

3-(8-hydroxy-quinolin-2-yl)-acrylicacid 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C(=C1)O)N=C(C=C2)C=CC(=O)O

Technology Process of 3-(8-Hydroxyquinolin-2-YL)prop-2-enoic acid

There total 5 articles about 3-(8-Hydroxyquinolin-2-YL)prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 93985-78-5
ethyl (E)-3-(8-hydroxyquinolin-2-yl)acrylate

: 91493-45-7
(E)-3-(8-hydroxyquinolin-2-yl)acrylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 0 - 25 ℃; for 1h;
DOI:10.1016/j.ejmech.2021.113153

Reference yield:

: 14510-06-6
2-formyl oxine

: 91493-45-7
(E)-3-(8-hydroxyquinolin-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / toluene / 2 h / 25 °C / Molecular sieve; Darkness

2: lithium hydroxide; water / tetrahydrofuran / 1 h / 0 - 25 °C

With water; sodium hydride; lithium hydroxide; In tetrahydrofuran; toluene;
DOI:10.1016/j.ejmech.2021.113153

Reference yield:

: 826-81-3
2-methyl-8-quinolinol

: 91493-45-7
(E)-3-(8-hydroxyquinolin-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: selenium(IV) oxide; pyridine / 1,4-dioxane; water / 105 °C

2: sodium hydride / toluene / 2 h / 25 °C / Molecular sieve; Darkness

3: lithium hydroxide; water / tetrahydrofuran / 1 h / 0 - 25 °C

With pyridine; selenium(IV) oxide; water; sodium hydride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; toluene;
DOI:10.1016/j.ejmech.2021.113153