(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Base Information

Chemical Name:(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
CAS No.:1204221-28-2
Molecular Formula:C₂₂H₂₅ClO₅
Molecular Weight:405.883
Hs Code.:

Synonyms:(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

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Chemical Property of (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

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Technology Process of (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

There total 5 articles about (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204221-26-0
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 1204221-28-2
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 879545-40-1
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 1204221-28-2
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium dichromate; acetic acid / 22 h / 120 °C

2.1: methanol; sodium borodeuteride / tetrahydrofuran / 0 - 20 °C

3.1: toluene-4-sulfonic acid / water; toluene / 1 h / 120 °C

4.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 0 °C / Inert atmosphere

4.2: 20 °C

5.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C

With methanol; potassium dichromate; sodium borodeuteride; lithium hydroxide monohydrate; water; diethylzinc; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene;

Reference yield:

: 1118566-90-7
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(4-acetylbenzyl)-4-chlorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 1204221-28-2
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sodium borodeuteride / tetrahydrofuran / 0 - 20 °C

2.1: toluene-4-sulfonic acid / water; toluene / 1 h / 120 °C

3.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 0 °C / Inert atmosphere

3.2: 20 °C

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C

With methanol; sodium borodeuteride; lithium hydroxide monohydrate; water; diethylzinc; toluene-4-sulfonic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene;