(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Base Information

Chemical Name:(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
CAS No.:1204221-26-0
Molecular Formula:C₃₀H₃₃ClO₉
Molecular Weight:574.032
Hs Code.:

Synonyms:(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

There total 4 articles about (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-11-6
diiodomethane

: 1204221-24-8
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(vinyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 1204221-26-0
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: diiodomethane; With diethylzinc; trifluoroacetic acid; In hexane; dichloromethane; at 0 ℃; Inert atmosphere;

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(vinyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate; In hexane; dichloromethane; at 20 ℃;

Reference yield:

: 879545-40-1
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 1204221-26-0
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium dichromate; acetic acid / 22 h / 120 °C

2.1: methanol; sodium borodeuteride / tetrahydrofuran / 0 - 20 °C

3.1: toluene-4-sulfonic acid / water; toluene / 1 h / 120 °C

4.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 0 °C / Inert atmosphere

4.2: 20 °C

With methanol; potassium dichromate; sodium borodeuteride; diethylzinc; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; water; toluene;

Reference yield:

: 1118566-90-7
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(4-acetylbenzyl)-4-chlorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 1204221-26-0
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(cyclopropyl-1-d)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol; sodium borodeuteride / tetrahydrofuran / 0 - 20 °C

2.1: toluene-4-sulfonic acid / water; toluene / 1 h / 120 °C

3.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 0 °C / Inert atmosphere

3.2: 20 °C

With methanol; sodium borodeuteride; diethylzinc; toluene-4-sulfonic acid; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; water; toluene;