(E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate

Base Information

• Chemical Name: (E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate
• CAS No.: 1430695-52-5
• Molecular Formula: C₃₁H₂₇F₃O₆
• Molecular Weight: 552.547
• Mol file: 1430695-52-5.mol

Synonyms:(E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate

Chemical Property of (E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate

There total 8 articles about (E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(E)-3-(3-hydroxy-4-methoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)prop-2-en-1-one (1430695-92-3) + 2-oxo-m-trifluoromethyl-3-phenylpropionic acid (120658-70-0) → (E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate (1430695-52-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2013.01.007

Reference yield: 45.0%

3-(trifluoromethyl)phenylacetic acid (351-35-9) + (E)-3-(3-hydroxy-4-methoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)prop-2-en-1-one (1430695-92-3) → (E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate (1430695-52-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

isovanillin (621-59-0) → (E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate (1430695-52-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 °C

1.2: 2 h / 20 °C

2.1: sodium hydroxide / water; methanol / 20 °C

3.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

With hydrogenchloride; dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; water; ethyl acetate; acetonitrile; 2.1: |Claisen-Schmidt Condensation;

DOI:10.1016/j.ejmech.2013.01.007

upstream raw materials:

isovanillin

1-(2-hydroxy-4-methoxyphenyl)ethanone

1-(4-methoxy-2-((2-methylbut-3-yn-2-yl)oxy)phenyl)ethanone

1-(5-methoxy-2, 2-dimethyl-2H-chromen-8-yl)ethan-1-one