120658-70-0

Basic information

• Product Name: 2-oxo-m-trifluoromethyl-3-phenylpropionic acid
• Synonyms: 2-oxo-m-trifluoromethyl-3-phenylpropionic acid
• CAS NO: 120658-70-0
• Molecular Weight: 232.159
• Mol File: 120658-70-0.mol

Chemical Properties

• CAS DataBase Reference: 2-oxo-m-trifluoromethyl-3-phenylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-m-trifluoromethyl-3-phenylpropionic acid(120658-70-0)
• EPA Substance Registry System: 2-oxo-m-trifluoromethyl-3-phenylpropionic acid(120658-70-0)

Safety Data

• Hazardous Substances Data: 120658-70-0(Hazardous Substances Data)

Upstream product

• 76605-42-0 5-(3-trifluoromethylbenzylidene)imidazoline-2,4-dione 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 564441-49-2 (Z)-2-methyl-4-[3-(trifluoromethyl)benzylidene]-5(4H)-oxazolone 
• 3094-33-5 (Z,E)-2-acetylamino-3-(3-trifluoromethyl-phenyl)-acrylic acid 

Downstream Products

• 139115-18-7 3-methyl-2-oxo-3-(3-trifluoromethyl-phenyl)-butyric acid 
• 226256-56-0 cinacalcet 
• 364782-34-3 cinacalcet hydrochloride 
• 866087-60-7 (R)-2-hydroxy-3-(3-trifluoromethyl-phenyl)-propionic acid 
• 63701-37-1 2-amino-3-(3-trifluoromethylphenyl)propanoic acid 
• 80980-59-2 racemic 15-formyl-14-hydroxy-5,5-dimethyl-2,8-dithia<9>(2,5)pyridinophane 
• 1430695-52-5 (E)-2-methoxy-5-(3-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-oxoprop-1-en-1-yl)phenyl 2-(3-(trifluoromethyl)phenyl)acetate 

Relevant articles and documents

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The invention relates to a preparation method of cinacalcet hydrochloride. The preparation method comprises the following steps: taking m-trifluoromethyl benzaldehyde, hydantoin and (R)-1-(1-naphthyl)ethylamine as raw materials, performing condensation, hydrolysis, amidation and reduction reaction to prepare cinacalcet, and reacting cinacalcet with hydrochloric acid to prepare cinacalcet hydrochloride. Compared with an existing synthesis method of cinacalcet hydrochloride, the preparation method is short in route and low in raw material cost, the adopted condensing agent is oxalyl chloride and thionyl chloride, which are low in price, the adopted reducing agent is sodium borohydride, which is low in price, a precious metal catalyst (palladium on carbon) is not used, the hydrogenation reaction step is avoided, the requirement for equipment is low, normal-pressure reaction operation can be adopted, and the method is suitable for large-scale industrial production.

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