6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Base Information

• Chemical Name: 6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine
• CAS No.: 82892-58-8
• Molecular Formula: C₃₅H₄₉N₅O₄S₂Si₂
• Molecular Weight: 724.108

Synonyms:6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Chemical Property of 6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

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Technology Process of 6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

There total 3 articles about 6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-Deoxyguanosine (961-07-9) → 6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine (82892-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 168 h / Ambient temperature

2: pyridine / 5 h / Ambient temperature

In pyridine;

DOI:10.1021/ja00385a026

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine (82892-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 168 h / Ambient temperature

2: pyridine / 5 h / Ambient temperature

In pyridine;

DOI:10.1021/ja00385a026

Reference yield:

phenyl chlorothioformate (13464-19-2) + 3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (51549-35-0) → 6-(phenylthio)-2-N-(phenylthiocarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine (82892-58-8)

Guidance literature:

In pyridine; for 5h; Yield given; Ambient temperature;

DOI:10.1021/ja00385a026

upstream raw materials:

phenyl chlorothioformate

3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

2'-Deoxyguanosine

tert-butyldimethylsilyl chloride

Downstream raw materials:

{6-Benzyloxy-9-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-carbamic acid benzyl ester

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