N-n-propyl-4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo-[2,1-f][1,2,4]triazine-6-carboxamide

Base Information

• Chemical Name: N-n-propyl-4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo-[2,1-f][1,2,4]triazine-6-carboxamide
• CAS No.: 427877-71-2
• Molecular Formula: C₂₀H₂₄N₆O₃
• Molecular Weight: 396.449
• Mol file: 427877-71-2.mol

Synonyms:N-n-propyl-4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo-[2,1-f][1,2,4]triazine-6-carboxamide

Chemical Property of N-n-propyl-4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo-[2,1-f][1,2,4]triazine-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-n-propyl-4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo-[2,1-f][1,2,4]triazine-6-carboxamide

There total 1 articles about N-n-propyl-4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo-[2,1-f][1,2,4]triazine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid (1005196-62-2) + N-propylamine hydrochloride (556-53-6) → N-n-propyl-4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo-[2,1-f][1,2,4]triazine-6-carboxamide (427877-71-2)

Guidance literature:

4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid; N-propylamine hydrochloride; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 0.5h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 8h; Further stages.;

DOI:10.1021/jm7009414

Reference yield: 95.0%

N-n-propyl-4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo-[2,1-f][1,2,4]triazine-6-carboxamide (427877-71-2) → 4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoic acid (623155-62-4)

Guidance literature:

With hydrogenchloride; water; at 85 ℃; for 6.5h;

DOI:10.1021/jm100540x

upstream raw materials:

4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

N-propylamine hydrochloride

Downstream raw materials:

4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoic acid