Propylamine hydrochloride

Base Information

• Chemical Name: Propylamine hydrochloride
• CAS No.: 556-53-6
• Molecular Formula: C3H10ClN
• Molecular Weight: 95.5721
• Hs Code.: 29211990
• European Community (EC) Number: 209-129-9
• NSC Number: 210913
• UNII: A1Z6OVY2HG
• DSSTox Substance ID: DTXSID0060301
• Wikidata: Q27273520
• Mol file: 556-53-6.mol

Synonyms:PROPYLAMINE HYDROCHLORIDE;556-53-6;propan-1-amine hydrochloride;n-Propylamine hydrochloride;1-Propanamine, hydrochloride;Propylammonium chloride;1-Propylammonium chloride;Propan-1-amine;hydrochloride;n-Propylammonium chloride;Propylamine, hydrochloride;N-Propylamine HCl;1-Aminopropane hydrochloride;EINECS 209-129-9;UNII-A1Z6OVY2HG;A1Z6OVY2HG;1-Propanamine, hydrochloride (1:1);NSC 210913;NSC-210913;N-PROPYL-D7-AMINE HCL;MFCD00012911;344298-88-0;n-PrNH2.HCl;C(C)CN;1-Propanamine hydrochloride;DTXSID0060301;Propylamine hydrochloride, >=99%;Propylamine Hydrochloride, >/=98%;NSC210913;PROPYLAMINE HYDROCHLORIDE [MI];AKOS015950694;SB75356;AS-59473;LS-125701;CS-0079898;FT-0693876;P0522;EN300-55115;D74104;A870142;Q27273520

Chemical Property of Propylamine hydrochloride

Chemical Property:

• Appearance/Colour: WHITE TO VERY SLIGHTLY BEIGE CRYSTALLINE POWDER
• Vapor Pressure: 329mmHg at 25°C
• Melting Point: 160-162 °C (lit.)
• Refractive Index: 1.4413 (estimate)
• Boiling Point: 46.9 °C at 760 mmHg
• PSA: 26.02000
• Density: 0.9337 (rough estimate)
• LogP: 1.85740
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: water: soluble100mg/mL, clear, colorless
• Water Solubility.: almost transparency
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 95.0501770
• Heavy Atom Count: 5
• Complexity: 7.2

Purity/Quality:

1-AminopropaneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCN.Cl
• Uses: Propylamine hydrochloride was used to study the liquid chromatographic behavior of potassium-sparing and loop diuretics.

Technology Process of Propylamine hydrochloride

There total 12 articles about Propylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

propiononitrile (107-12-0) → N-propylamine hydrochloride (556-53-6)

Guidance literature:

propiononitrile; With [Ru(H)(BH₄)(CO)(PPh₃)(3-(di-tert-butylphosphino)-N-((1-methyl-1H-imidazol-2 yl)methyl)propylamine)]; hydrogen; In isopropyl alcohol; at 70 ℃; for 3h; Inert atmosphere; Autoclave;

With hydrogenchloride; In methanol; isopropyl alcohol; at 20 ℃; for 0.5h; Inert atmosphere; Autoclave;

DOI:10.1002/chem.201504709

Reference yield: 98.0%

N,N-Bis(trimethylsilyl)propylamin (7331-84-2) → Hexamethyldisiloxane (107-46-0) + N-propylamine hydrochloride (556-53-6)

Guidance literature:

With hydrogenchloride;

Reference yield: 92.0%

butanamide (541-35-5) → N-propylamine hydrochloride (556-53-6)

Guidance literature:

butanamide; With tetrafluoroboric acid; iodobenzene; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at 25 ℃; for 48h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water; Inert atmosphere;

DOI:10.1039/c2cc16360h

upstream raw materials:

N,N-Bis(trimethylsilyl)propylamin

N-Nitroso-N-propyl-1-methoxyethylamine

propanaminium propylcarbamate

benzoyl chloride

Downstream raw materials:

N,N-dimethylaminopropane

propyl-(2-[2]pyridyl-ethyl)-amine

N'-(4-methylphenyl)-N-propylformamidine

propan-1-ol

Refernces

• 1、 Bera, Jitendra K.,Pandey, Pragati. "Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex". supporting information. p. 9204 - 9207. Retrieved 2021/09/20.
• 2、 Bhunia, Mrinal,Sahoo, Sumeet Ranjan,Das, Arpan,Ahmed, Jasimuddin,Sreejyothi,Mandal, Swadhin K.. "Transition metal-free catalytic reduction of primary amides using an abnormal NHC based potassium complex: Integrating nucleophilicity with Lewis acidic activation". . p. 1848 - 1854. Retrieved 2020/03/03.