(S)-tert-butyl 2-(5-(benzyloxy)-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoyl)hydrazine carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-(5-(benzyloxy)-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoyl)hydrazine carboxylate
CAS No.:1539279-72-5
Molecular Formula:C₂₅H₃₁N₃O₇
Molecular Weight:485.537
Hs Code.:

Synonyms:(S)-tert-butyl 2-(5-(benzyloxy)-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoyl)hydrazine carboxylate

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Chemical Property of (S)-tert-butyl 2-(5-(benzyloxy)-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoyl)hydrazine carboxylate

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Technology Process of (S)-tert-butyl 2-(5-(benzyloxy)-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoyl)hydrazine carboxylate

There total 1 articles about (S)-tert-butyl 2-(5-(benzyloxy)-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoyl)hydrazine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 870-46-2
t-butoxycarbonylhydrazine

: 3705-42-8
Cbz-(L)-Glu-OBn

: 1539279-72-5
(S)-tert-butyl 2-(5-(benzyloxy)-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoyl)hydrazine carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/psc.2596

Reference yield:

: 1539279-72-5
(S)-tert-butyl 2-(5-(benzyloxy)-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoyl)hydrazine carboxylate

: L-N-Carbobenzoxy-glutaminsaeure-α-benzylester-γ-hydrazid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.1002/psc.2596

Reference yield:

: 1539279-72-5
(S)-tert-butyl 2-(5-(benzyloxy)-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoyl)hydrazine carboxylate

: 1539279-74-7
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(2-((2-chlorophenyl)diphenylmethyl)hydrazinyl)-5-oxopentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1002/psc.2596