7-biphenyl-4-ylmethyl-N⁽⁴⁾-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: 7-biphenyl-4-ylmethyl-N⁽⁴⁾-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
• CAS No.: 1369493-25-3
• Molecular Formula: C₂₅H₂₀BrN₅
• Molecular Weight: 470.371

Synonyms:7-biphenyl-4-ylmethyl-N⁽⁴⁾-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Chemical Property of 7-biphenyl-4-ylmethyl-N⁽⁴⁾-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of 7-biphenyl-4-ylmethyl-N⁽⁴⁾-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

There total 3 articles about 7-biphenyl-4-ylmethyl-N⁽⁴⁾-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

biphenyl-4-methylchloride (1667-11-4) + N4-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1369493-27-5) → 7-biphenyl-4-ylmethyl-N(4)-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1369493-25-3)

Guidance literature:

N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

biphenyl-4-methylchloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2012.01.029

Reference yield:

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (84955-31-7) → 7-biphenyl-4-ylmethyl-N(4)-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1369493-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; isopropyl alcohol / 4 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 20 °C

With hydrogenchloride; sodium hydride; In water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmc.2012.01.029

Reference yield:

2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (7355-55-7) → 7-biphenyl-4-ylmethyl-N(4)-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1369493-25-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N-dimethyl-aniline; trichlorophosphate / 4 h / Reflux

1.2: pH 7 / Cooling with ice

2.1: hydrogenchloride / water; isopropyl alcohol / 4 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 20 °C

With hydrogenchloride; sodium hydride; N,N-dimethyl-aniline; trichlorophosphate; In water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmc.2012.01.029

upstream raw materials:

biphenyl-4-methylchloride

N⁴-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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