Technology Process of (3S,4S)-1-(4-methoxybenzyl)-3,4-dibenzyloxy-2,5-pyrrolidinedione
There total 1 articles about (3S,4S)-1-(4-methoxybenzyl)-3,4-dibenzyloxy-2,5-pyrrolidinedione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
L-O,O-dibenzyltartaric acid;
With
acetyl chloride;
for 4h;
Heating;
4-methoxy-benzylamine;
In
dichloromethane;
for 5h;
Heating;
With
acetyl chloride;
for 6h;
Further stages.;
Heating;
DOI:10.1016/j.tet.2007.02.087
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 81 percent / magnesium; mercury(II) chloride / tetrahydrofuran / 7 h / 20 °C
2: 777 mg / triethylsilane; boron trifluoride etherate / CH2Cl2 / -78 - 20 °C
3: 85 percent / ceric ammonium nitrate / acetonitrile; H2O / 5.5 h / 0 - 20 °C
4: 10 percent / BH3*SMe2 / tetrahydrofuran / 0 - 20 °C
5: 80 percent / K2CO3 / methanol / 48 h / 20 °C
With
triethylsilane; ammonium cerium(IV) nitrate; dimethylsulfide borane complex; boron trifluoride diethyl etherate; potassium carbonate; magnesium; mercury dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
1: Grignard reaction;
DOI:10.1016/j.tet.2007.02.087
