1-(1,1-dimethylethyl)-5-hydroxy-4-(3-iodo-2-methyl-4-methylsulfonylbenzoyl)pyrazole

Base Information

Chemical Name:1-(1,1-dimethylethyl)-5-hydroxy-4-(3-iodo-2-methyl-4-methylsulfonylbenzoyl)pyrazole
CAS No.:216485-70-0
Molecular Formula:C₁₆H₁₉IN₂O₄S
Molecular Weight:462.308
Hs Code.:

Synonyms:1-(1,1-dimethylethyl)-5-hydroxy-4-(3-iodo-2-methyl-4-methylsulfonylbenzoyl)pyrazole

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Chemical Property of 1-(1,1-dimethylethyl)-5-hydroxy-4-(3-iodo-2-methyl-4-methylsulfonylbenzoyl)pyrazole

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Technology Process of 1-(1,1-dimethylethyl)-5-hydroxy-4-(3-iodo-2-methyl-4-methylsulfonylbenzoyl)pyrazole

There total 5 articles about 1-(1,1-dimethylethyl)-5-hydroxy-4-(3-iodo-2-methyl-4-methylsulfonylbenzoyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 216486-04-3
3-chloro-2-methyl-4-(methylsulfonyl)benzoic acid

: 216485-70-0
1-(1,1-dimethylethyl)-5-hydroxy-4-(3-iodo-2-methyl-4-methylsulfonylbenzoyl)pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 68 percent / NH₄OH; CuO / H₂O / 17 h / 180 °C

2.1: NaNO₂; H₂SO₄ / H₂O / 30 h / 5 °C

2.2: 90 percent / KI / H₂O / 0.5 h / 80 °C

3.1: SOCl₂ / 1,2-dichloro-ethane / 3 h / Heating

4.1: (CH₃CH₂)3N

4.2: CN^(1-)

With ammonium hydroxide; thionyl chloride; sulfuric acid; triethylamine; copper(II) oxide; sodium nitrite; In water; 1,2-dichloro-ethane;
DOI:10.1002/ps.588

Reference yield:

: 216485-68-6
3-iodo-2-methyl-4-(methylsulfonyl)benzoic acid

: 216485-70-0
1-(1,1-dimethylethyl)-5-hydroxy-4-(3-iodo-2-methyl-4-methylsulfonylbenzoyl)pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: SOCl₂ / 1,2-dichloro-ethane / 3 h / Heating

2.1: (CH₃CH₂)3N

2.2: CN^(1-)

With thionyl chloride; triethylamine; In 1,2-dichloro-ethane;
DOI:10.1002/ps.588

Reference yield:

: 496805-63-1
2,6-dichloro-3-(methylsulfonyl)toluene

: 216485-70-0
1-(1,1-dimethylethyl)-5-hydroxy-4-(3-iodo-2-methyl-4-methylsulfonylbenzoyl)pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 86 percent / Pd(OAc)2; NaHCO₃; 1,4-bis(diphenylphosphino)butane / 2-methyl-propan-2-ol; H₂O / 20 h / 125 °C / 15001.2 Torr

2.1: 68 percent / NH₄OH; CuO / H₂O / 17 h / 180 °C

3.1: NaNO₂; H₂SO₄ / H₂O / 30 h / 5 °C

3.2: 90 percent / KI / H₂O / 0.5 h / 80 °C

4.1: SOCl₂ / 1,2-dichloro-ethane / 3 h / Heating

5.1: (CH₃CH₂)3N

5.2: CN^(1-)

With palladium diacetate; ammonium hydroxide; thionyl chloride; sulfuric acid; sodium hydrogencarbonate; triethylamine; 1,4-di(diphenylphosphino)-butane; copper(II) oxide; sodium nitrite; In water; 1,2-dichloro-ethane; tert-butyl alcohol;
DOI:10.1002/ps.588