Technology Process of Methanone,
[1-(1,1-dimethylethyl)-5-hydroxy-1H-pyrazol-4-yl][4'-methoxy-2-methyl-6-
(methylsulfonyl)[1,1'-biphenyl]-3-yl]-
There total 8 articles about Methanone,
[1-(1,1-dimethylethyl)-5-hydroxy-1H-pyrazol-4-yl][4'-methoxy-2-methyl-6-
(methylsulfonyl)[1,1'-biphenyl]-3-yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(1,1-dimethyl-1-ethyl)-5-hydroxy-1H-pyrazole; 6-methanesulfonyl-4'-methoxy-2-methyl-biphenyl-3-carbonyl chloride;
With
triethylamine;
In
dichloromethane;
at 5 - 20 ℃;
With
potassium carbonate;
2-hydroxy-2-methylpropanenitrile;
In
acetonitrile;
DOI:10.1002/ps.588
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 86 percent / Pd(OAc)2; NaHCO3; 1,4-bis(diphenylphosphino)butane / 2-methyl-propan-2-ol; H2O / 20 h / 125 °C / 15001.2 Torr
2.1: 68 percent / NH4OH; CuO / H2O / 17 h / 180 °C
3.1: NaNO2; H2SO4 / H2O / 30 h / 5 °C
3.2: 90 percent / KI / H2O / 0.5 h / 80 °C
4.1: 84 percent / K2CO3 / Pd(OAc)2; P(o-Tol)3 / bis-(2-methoxy-ethyl) ether; H2O / 12 h / 95 °C
5.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating
6.1: (CH3CH2)3N / CH2Cl2 / 5 - 20 °C
6.2: 10.9 g / K2CO3 / (CH3)2C(CN)OH / acetonitrile
With
palladium diacetate; ammonium hydroxide; thionyl chloride; sulfuric acid; sodium hydrogencarbonate; potassium carbonate; triethylamine; 1,4-di(diphenylphosphino)-butane; copper(II) oxide; sodium nitrite;
palladium diacetate; tris-(o-tolyl)phosphine;
In
dichloromethane; diethylene glycol dimethyl ether; water; 1,2-dichloro-ethane; tert-butyl alcohol;
4.1: Suzuki condensation;
DOI:10.1002/ps.588
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaNO2; H2SO4 / H2O / 30 h / 5 °C
1.2: 90 percent / KI / H2O / 0.5 h / 80 °C
2.1: 84 percent / K2CO3 / Pd(OAc)2; P(o-Tol)3 / bis-(2-methoxy-ethyl) ether; H2O / 12 h / 95 °C
3.1: SOCl2 / 1,2-dichloro-ethane / 3 h / Heating
4.1: (CH3CH2)3N / CH2Cl2 / 5 - 20 °C
4.2: 10.9 g / K2CO3 / (CH3)2C(CN)OH / acetonitrile
With
thionyl chloride; sulfuric acid; potassium carbonate; triethylamine; sodium nitrite;
palladium diacetate; tris-(o-tolyl)phosphine;
In
dichloromethane; diethylene glycol dimethyl ether; water; 1,2-dichloro-ethane;
2.1: Suzuki condensation;
DOI:10.1002/ps.588
