3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methylamine)propanoic acid TFA

Base Information

Chemical Name:3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methylamine)propanoic acid TFA
CAS No.:1307809-72-8
Molecular Formula:C₂HF₃O₂*C₂₅H₂₅N₃O₄
Molecular Weight:545.515
Hs Code.:

Synonyms:3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methylamine)propanoic acid TFA

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Chemical Property of 3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methylamine)propanoic acid TFA

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Technology Process of 3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methylamine)propanoic acid TFA

There total 5 articles about 3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methylamine)propanoic acid TFA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.3%

: 1307812-67-4
5-(7-formyl-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: 76-05-1
trifluoroacetic acid

: 1307809-72-8
3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methylamine)propanoic acid TFA

Guidance literature:: 5-(7-formyl-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile; tert-butyl 3-aminopropanoate hydrochloride; With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

acetic acid; In dichloromethane; at 20 ℃; for 1.5h;

trifluoroacetic acid;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1307809-72-8
3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methylamine)propanoic acid TFA

Guidance literature:: Multi-step reaction with 5 steps

1.1: diazomethyl-trimethyl-silane / dichloromethane / 1.8 h / 0 - 20 °C

1.2: 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.27 h / 0 °C

2.2: 0.18 h / 0 °C

2.3: 0.42 h / 20 - 110 °C / Sonication

3.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Sealed tube

4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 3.5 h / 20 °C

4.2: 1.03 h / 20 °C

5.1: triethylamine; sodium tris(acetoxy)borohydride / dichloromethane / 0.5 h / 20 °C

5.2: 1.5 h / 20 °C

With osmium(VIII) oxide; sodium tris(acetoxy)borohydride; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; lithium diisopropyl amide; diazomethyl-trimethyl-silane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 213598-11-9
methyl 3-cyano-4-[(1-methylethyl)oxy]benzoate

: 1307809-72-8
3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methylamine)propanoic acid TFA

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.27 h / 0 °C

1.2: 0.18 h / 0 °C

1.3: 0.42 h / 20 - 110 °C / Sonication

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Sealed tube

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 3.5 h / 20 °C

3.2: 1.03 h / 20 °C

4.1: triethylamine; sodium tris(acetoxy)borohydride / dichloromethane / 0.5 h / 20 °C

4.2: 1.5 h / 20 °C

With osmium(VIII) oxide; sodium tris(acetoxy)borohydride; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;