N-cyclopropyl-4-methyl-3-(1-oxo-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

Base Information

Chemical Name:N-cyclopropyl-4-methyl-3-(1-oxo-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide
CAS No.:1070295-81-6
Molecular Formula:C₂₆H₂₉N₃O₂
Molecular Weight:415.535
Hs Code.:

Synonyms:N-cyclopropyl-4-methyl-3-(1-oxo-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

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Chemical Property of N-cyclopropyl-4-methyl-3-(1-oxo-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

Chemical Property:

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Technology Process of N-cyclopropyl-4-methyl-3-(1-oxo-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

There total 4 articles about N-cyclopropyl-4-methyl-3-(1-oxo-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070295-83-8
4-[6-(5-cyclopropylcarbamoyl-2-methylphenyl)-1-oxo-1H-isoquinolin-2-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester

: 1070295-81-6
N-cyclopropyl-4-methyl-3-(1-oxo-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070295-81-6
N-cyclopropyl-4-methyl-3-(1-oxo-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h

3: caesium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

With hydrogenchloride; isopropylmagnesium chloride; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 82827-09-6
6-bromo-2H-isoquinoline-1-one

: 1070295-81-6
N-cyclopropyl-4-methyl-3-(1-oxo-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h

3: caesium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

With hydrogenchloride; isopropylmagnesium chloride; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;