N-(5-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylacetamide

Base Information

• Chemical Name: N-(5-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylacetamide
• CAS No.: 1415397-18-0
• Molecular Formula: C₁₆H₁₈N₆OS₂
• Molecular Weight: 374.491
• Mol file: 1415397-18-0.mol

Synonyms:N-(5-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylacetamide

Chemical Property of N-(5-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylacetamide

There total 9 articles about N-(5-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid (1415397-86-2) + thiosemicarbazide (79-19-6) → N-(5-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylacetamide (1415397-18-0)

Guidance literature:

With trichlorophosphate; at 85 ℃; for 4h;

DOI:10.1021/jm301191p

Reference yield:

C15H16N4OS (1439400-15-3) + thiosemicarbazide (79-19-6) → N-(5-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylacetamide (1415397-18-0)

Guidance literature:

With trifluoroacetic acid; at 70 ℃; Inert atmosphere;

Reference yield:

phenylacetic acid (103-82-2) + 5,5′-(butane-1,4-diyl)bis(1,3,4-thiadiazol-2-amine) (98558-04-4) → N-(5-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylacetamide (1415397-18-0)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b01198

upstream raw materials:

5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid

thiosemicarbazide

methyl adipoyl chloride

5-(5-amino-1,3,4-thiadiazol-2-yl)pentanoic acid

Downstream raw materials:

C₃₀H₃₅N₇O₄S₂

2-phenyl-N-(5-(4-(5-(2-(pyridin-2-yl)acetamido)-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide

2-phenyl-N-(5-(4-(5-(2-(pyridin-3-yl)acetamido)-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide