5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid

Base Information

• Chemical Name: 5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid
• CAS No.: 1415397-86-2
• Molecular Formula: C₁₅H₁₇N₃O₃S
• Molecular Weight: 319.384
• Mol file: 1415397-86-2.mol

Synonyms:5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid

Chemical Property of 5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid

There total 4 articles about 5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-(5-amino-1,3,4-thiadiazol-2-yl)pentanoic acid (118863-95-9) + phenylacetyl chloride (103-80-0) → 5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid (1415397-86-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 48h;

DOI:10.1021/jm301191p

Reference yield: 90.4%

ethyl 5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoate → 5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid (1415397-86-2)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.9b01035

Reference yield:

adipinic acid monoethyl ester (626-86-8) → 5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanoic acid (1415397-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 4 h / 85 °C

2: triethylamine / tetrahydrofuran / 20 °C

3: sodium hydroxide / methanol / 3 h / 20 °C

With triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol;

DOI:10.1021/acs.jmedchem.9b01035

upstream raw materials:

5-(5-amino-1,3,4-thiadiazol-2-yl)pentanoic acid

phenylacetyl chloride

adipinic acid monoethyl ester

Downstream raw materials:

tert-butyl 2-(5-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)pentanamido)ethylcarbamate

C₂₃H₂₃F₃N₄O₂S

C₂₄H₂₉N₅O₂S

C₂₂H₂₄N₄O₂S