benzyl (2S)-2-{[(2S)-2-hydroxypropanoyl]amino}-3-methylbutanoate

Base Information

• Chemical Name: benzyl (2S)-2-{[(2S)-2-hydroxypropanoyl]amino}-3-methylbutanoate
• CAS No.: 1181104-59-5
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 1181104-59-5.mol

Synonyms:benzyl (2S)-2-{[(2S)-2-hydroxypropanoyl]amino}-3-methylbutanoate

Chemical Property of benzyl (2S)-2-{[(2S)-2-hydroxypropanoyl]amino}-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of benzyl (2S)-2-{[(2S)-2-hydroxypropanoyl]amino}-3-methylbutanoate

There total 2 articles about benzyl (2S)-2-{[(2S)-2-hydroxypropanoyl]amino}-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

L-Lactic acid (79-33-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + L-valine benzyl ester p-toluenesulfonate salt (16652-76-9) → benzyl (2S)-2-{[(2S)-2-hydroxypropanoyl]amino}-3-methylbutanoate (1181104-59-5)

Guidance literature:

With benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2009.05.051

Reference yield:

L-Lactic acid (79-33-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + L-valine benzyl ester p-toluenesulfonate salt (16652-76-9) → benzyl (2S)-2-{[(2S)-2-hydroxypropanoyl]amino}-3-methylbutanoate (1181104-59-5) + C15H21NO4

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; optical yield given as %de;

DOI:10.1002/psc.1254

Reference yield: 72.0%

benzyl (2S)-2-{[(2S)-2-hydroxypropanoyl]amino}-3-methylbutanoate (1181104-59-5) + benzyl hydrogen [(R,S)-1-(benzyloxycarbonylamino)pent-1-yl]phosphonate (106019-45-8) → benzyl (2S)-2-{[(2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoyl]amino}-3-methylbutanoate (1043504-74-0)

Guidance literature:

With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2008.05.028

upstream raw materials:

L-Lactic acid

L-valine benzyl ester p-toluenesulfonate salt

Downstream raw materials:

benzyl (2S)-2-{[(2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoyl]amino}-3-methylbutanoate