(2E,4E)-2-Cyano-5-phenyl-penta-2,4-dienethioic acid S-tert-butyl ester

Base Information

• Chemical Name: (2E,4E)-2-Cyano-5-phenyl-penta-2,4-dienethioic acid S-tert-butyl ester
• CAS No.: 83576-46-9
• Molecular Formula: C₁₆H₁₇NOS
• Molecular Weight: 271.383
• Mol file: 83576-46-9.mol

Synonyms:(2E,4E)-2-Cyano-5-phenyl-penta-2,4-dienethioic acid S-tert-butyl ester

Chemical Property of (2E,4E)-2-Cyano-5-phenyl-penta-2,4-dienethioic acid S-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E)-2-Cyano-5-phenyl-penta-2,4-dienethioic acid S-tert-butyl ester

There total 1 articles about (2E,4E)-2-Cyano-5-phenyl-penta-2,4-dienethioic acid S-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-tert-butyl cyanothiolacetate (75839-80-4) + 3-phenyl-propenal (104-55-2) → (2E,4E)-2-Cyano-5-phenyl-penta-2,4-dienethioic acid S-tert-butyl ester (83576-46-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; for 20h; Ambient temperature;

DOI:10.1016/S0040-4039(00)88582-2

Reference yield: 78.0%

(2E,4E)-2-Cyano-5-phenyl-penta-2,4-dienethioic acid S-tert-butyl ester (83576-46-9) → (E)-2-Hydroxymethyl-5-phenyl-pent-4-enenitrile (83576-54-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(00)88582-2

Reference yield:

(2E,4E)-2-Cyano-5-phenyl-penta-2,4-dienethioic acid S-tert-butyl ester (83576-46-9) → (E)-2-Cyano-5-phenyl-pent-4-enethioic acid S-tert-butyl ester (83576-34-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.75h;

DOI:10.1016/S0040-4039(00)88582-2

upstream raw materials:

S-tert-butyl cyanothiolacetate

3-phenyl-propenal

Downstream raw materials:

(E)-2-Hydroxymethyl-5-phenyl-pent-4-enenitrile

(E)-2-Cyano-5-phenyl-pent-4-enethioic acid S-tert-butyl ester

(E)-2-Methylene-5-phenyl-pent-4-enenitrile

(E)-2-Ethyl-2-hydroxymethyl-5-phenyl-pent-4-enenitrile