N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide

Base Information

Chemical Name:N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide
CAS No.:1360632-28-5
Molecular Formula:C₅₀H₅₈N₄O₇S₃
Molecular Weight:923.231
Hs Code.:

N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide

Synonyms:N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide

Suppliers and Price of N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide

There total 11 articles about N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1360632-26-3
(S)-methyl-3-methyl-2-(4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)phenylsulfonamido)butanoate

: 1360632-28-5
N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1039/c1ob06304a

Reference yield:

: 952060-26-3
N-(2-nitrophenyl)-phenylalanine

: 1360632-28-5
N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: thionyl chloride / 0 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.08 h / 0 - 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 2585.81 Torr / Inert atmosphere

5: pyridine / 12 h / 0 °C

6: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

7: thionyl chloride / methanol / 0.08 h / 20 °C

8: pyridine / 12 h / 0 °C

9: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 3: Mitsunobu reaction / 6: Mitsunobu reaction;
DOI:10.1039/c1ob06304a

Reference yield:

: 1132769-58-4
(2S)-2-(2-nitrophenylamino)-3-phenylpropionic acid methyl ester

: 1360632-28-5
N-((S)-1-hydroxy-3-methylbutan-2-yl)-4-methyl-N-((S)-2-(2-(4-methyl-N-((S)-2-(4-methylphenylsulfonamido)-3-phenylpropyl)phenylsulfonamido)phenylamino)-3-phenylpropyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.08 h / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 2585.81 Torr / Inert atmosphere

4: pyridine / 12 h / 0 °C

5: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

6: thionyl chloride / methanol / 0.08 h / 20 °C

7: pyridine / 12 h / 0 °C

8: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 2: Mitsunobu reaction / 5: Mitsunobu reaction;
DOI:10.1039/c1ob06304a