2-Chloro-4-methoxyphenylacetic acid

Base Information

• Chemical Name: 2-Chloro-4-methoxyphenylacetic acid
• CAS No.: 91367-09-8
• Molecular Formula: C9H9 Cl O3
• Molecular Weight: 200.622
• Hs Code.: 2918990090
• European Community (EC) Number: 813-432-7
• DSSTox Substance ID: DTXSID00400869
• Wikidata: Q82203927
• Mol file: 91367-09-8.mol

Synonyms:91367-09-8;2-CHLORO-4-METHOXYPHENYLACETIC ACID;2-(2-chloro-4-methoxyphenyl)acetic acid;(2-chloro-4-methoxyphenyl)acetic acid;MFCD02664702;Benzeneacetic acid, 2-chloro-4-methoxy-;(2-chloro-4-methoxy-phenyl)-acetic acid;SCHEMBL473881;DTXSID00400869;KINVBFAPQYQPTG-UHFFFAOYSA-N;STK503900;AKOS005171598;FS-5882;2-(2-chloro-4-methoxyphenyl)aceticacid;SY140879;BB 0260088;CS-0039065;FT-0679211;BENZENEACETIC ACID,2-CHLORO-4-METHOXY-;EN300-107831;A843812

Chemical Property of 2-Chloro-4-methoxyphenylacetic acid

Chemical Property:

• PSA: 46.53000
• LogP: 1.97570
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 200.0240218
• Heavy Atom Count: 13
• Complexity: 184

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-chloro-4-methoxyphenyl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CC(=O)O)Cl

Technology Process of 2-Chloro-4-methoxyphenylacetic acid

There total 1 articles about 2-Chloro-4-methoxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-methoxyphenylacetonitrile (170737-93-6) → 2-(2-chloro-4-methoxyphenyl)acetic acid (91367-09-8)

Guidance literature:

With potassium hydroxide; In ethylene glycol;

Reference yield: 100.0%

2-(2-chloro-4-methoxyphenyl)acetic acid (91367-09-8) → 2-(2-chloro-4-methoxyphenyl)ethanol

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.10.034

Reference yield: 88.0%

2-(2-chloro-4-methoxyphenyl)acetic acid (91367-09-8) → methyl 2-(2-chloro-4-methoxyphenyl)acetate (847604-18-6)

Guidance literature:

With dmap; 1,2-dichloro-ethane; triethylamine; In methanol; n-heptane; dichloromethane; ethyl acetate;

upstream raw materials:

2-chloro-4-methoxyphenylacetonitrile

Downstream raw materials:

methyl 2-(2-chloro-4-methoxyphenyl)acetate

(2-chloro-4-methoxy-phenyl)-acetyl chloride

(2-chloro-4-methoxy-phenyl)-acetic acid ethyl ester

2-(2-chloro-4-methoxy-phenyl)-N-methyl-acetamide

Refernces

• 1、 -. "1-H-3-aryl-pyrrolidine-2, 4-dione derivatives as pest-control agents". . . Retrieved 2008/06/13.